Document Detail

Quantitative organic acid analysis in cerebrospinal fluid and plasma: reference values in a pediatric population.
MedLine Citation:
PMID:  8376520     Owner:  NLM     Status:  MEDLINE    
Quantitative reference values for the concentrations of organic acids in cerebrospinal fluid (CSF) and plasma, as well as ratios of individual organic acids between CSF and plasma, were determined in twenty-three pairs of samples from pediatric patients. Twenty-six organic acids were present and quantifiable in all or the majority of plasma and CSF specimens (limit of detection 1 mumol/l). There were substantial differences between subgroups of organic acids, best reflected by the ratios of individual acids between CSF and plasma. Metabolites related to fatty acid oxidation were present in CSF in substantially lower amounts than in plasma. Organic acids related to carbohydrate and energy metabolism and to amino acid degradation were present in CSF in equal or slightly lower amounts than in plasma. Finally, some organic acids were found in substantially higher amounts in CSF than in plasma, e.g. glycolate, glycerate, 2,4-dihydroxybutyrate, citrate and isocitrate. Quantitation of organic acids in CSF and plasma should aid diagnosis and monitoring of treatment of patients with organic acid disorders.
G F Hoffmann; C K Seppel; B Holmes; L Mitchell; H J Christen; F Hanefeld; D Rating; W L Nyhan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of chromatography     Volume:  617     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-18     Completed Date:  1993-10-18     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
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MeSH Terms
Acids / blood*,  cerebrospinal fluid*
Child, Preschool
Gas Chromatography-Mass Spectrometry
Reference Values
Grant Support
Reg. No./Substance:

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