| Quantitative near-infrared spectroscopy of cervical dysplasia in vivo. | |
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MedLine Citation:
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PMID: 10548647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aims of this study were: (i) to quantify near-infrared optical properties of normal cervical tissues and high-grade squamous intra-epithelial lesions (H-SIL); (ii) to assess the feasibility of differentiating normal cervical tissues from H-SIL on the basis of these properties; and (iii) to determine how cervical tissue optical properties change following photodynamic therapy (PDT) of H-SIL in vivo. Using the frequency domain photon migration technique, non-invasive measurements of normal and dysplastic ecto-cervical tissue optical properties, i.e. absorption (mu(a)) and effective scattering coefficients, and physiological parameters, i.e. tissue water and haemoglobin concentration, percentage oxygen saturation (%SO(2)), were performed on 10 patients scheduled for PDT of histologically-proven H-SIL. Cervix absorption and effective scattering parameters were up to 15% lower in H-SIL sites compared with normal cervical tissue for all wavelengths studied (674, 811, 849, 956 nm). Following PDT, all mu(a) values increased significantly, due to elevated tissue blood and water content associated with PDT-induced hyperaemia and oedema. Tissue total haemoglobin concentration ([TotHb]) and arterio-venous oxygen saturation measured in H-SIL sites were lower than normal sites ([TotHb]: 88.6 +/- 35.8 micromol/l versus 124.7 +/- 22.6 micromol/l; %SO(2): 76.5 +/- 14.7% versus 84.9 +/- 3.4%). |
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Authors:
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R Hornung; T H Pham; K A Keefe; M W Berns; Y Tadir; B J Tromberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 14 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-30 Completed Date: 1999-12-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2908-16 Citation Subset: IM |
Affiliation:
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Laser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, University of California (Irvine), CA 92612, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Cervical Intraepithelial Neoplasia / drug therapy, pathology Colposcopy Female Hemoglobins / analysis Humans Oxyhemoglobins / analysis Photochemotherapy Spectroscopy, Near-Infrared* Uterine Cervical Dysplasia / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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R29-GM50958/GM/NIGMS NIH HHS; RR-01192/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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