Document Detail


Quantitative morphological alterations during the development of furazolidone-induced cardiomyopathy in turkeys.
MedLine Citation:
PMID:  3944288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac structures were measured to determine the sequence of alterations during the development of spontaneous and furazolidone-induced cardiomyopathy in turkey poults 20 to 31 days after hatching. Samples of tissue from the free walls of the ventricles were removed and processed for electron microscopy. Volumetric density of cardiac structures was determined by the point-counting technique. The results indicate that the sequence of myocardial alterations is similar in both spontaneous and furazolidone-induced cardiomyopathy, but that these changes are more pronounced in the latter condition. Major changes include an early diminution in myofibrillar density, accompanied by a small reduction in mitochondrial density. This is followed by dilatation of the ventricular lumina and a decrease in the volume fraction of Z-bands. The increase in mass of the free walls of the ventricles in affected poults is due primarily to an increase in extracellular components and sarcoplasm devoid of organelles. The results suggest that the development of this myopathy is initiated by damage to the myofibrils of the cardiocytes.
Authors:
C M Czarnecki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  96     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-03     Completed Date:  1986-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  63-75     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Body Weight
Cardiomyopathies / chemically induced,  pathology,  veterinary*
Cell Nucleus / ultrastructure
Cytoplasm / ultrastructure
Electrocardiography
Furazolidone
Heart Ventricles / pathology
Male
Mitochondria, Heart / ultrastructure
Myocardium / ultrastructure
Myofibrils / ultrastructure
Poultry Diseases / pathology*
Turkeys
Chemical
Reg. No./Substance:
67-45-8/Furazolidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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