| Quantitative morphological alterations during the development of furazolidone-induced cardiomyopathy in turkeys. | |
| | |
MedLine Citation:
|
PMID: 3944288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiac structures were measured to determine the sequence of alterations during the development of spontaneous and furazolidone-induced cardiomyopathy in turkey poults 20 to 31 days after hatching. Samples of tissue from the free walls of the ventricles were removed and processed for electron microscopy. Volumetric density of cardiac structures was determined by the point-counting technique. The results indicate that the sequence of myocardial alterations is similar in both spontaneous and furazolidone-induced cardiomyopathy, but that these changes are more pronounced in the latter condition. Major changes include an early diminution in myofibrillar density, accompanied by a small reduction in mitochondrial density. This is followed by dilatation of the ventricular lumina and a decrease in the volume fraction of Z-bands. The increase in mass of the free walls of the ventricles in affected poults is due primarily to an increase in extracellular components and sarcoplasm devoid of organelles. The results suggest that the development of this myopathy is initiated by damage to the myofibrils of the cardiocytes. |
| | |
Authors:
|
C M Czarnecki |
Related Documents
:
|
12074338 - Ischemic dilatative cardiomyopathy and aneurysms of the left ventricular cavity: transp... 2278798 - Hypertrophic cardiomyopathy without hypertrophy: two families with myocardial disarray ... 20650608 - Hypertrophy pattern and regional myocardial mechanics are related in septal and apical ... 2784808 - Myocardial stunning in hypertrophic cardiomyopathy: recovery predicted by single photon... 22245798 - Subclinical left ventricular dysfunction revealed by circumferential 2d strain imaging ... 16350818 - The value of computed tomography-derived coronary artery calcification score in coronar... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of comparative pathology Volume: 96 ISSN: 0021-9975 ISO Abbreviation: J. Comp. Pathol. Publication Date: 1986 Jan |
Date Detail:
|
Created Date: 1986-03-03 Completed Date: 1986-03-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0102444 Medline TA: J Comp Pathol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 63-75 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Body Weight Cardiomyopathies / chemically induced, pathology, veterinary* Cell Nucleus / ultrastructure Cytoplasm / ultrastructure Electrocardiography Furazolidone Heart Ventricles / pathology Male Mitochondria, Heart / ultrastructure Myocardium / ultrastructure Myofibrils / ultrastructure Poultry Diseases / pathology* Turkeys |
| Chemical | |
Reg. No./Substance:
|
67-45-8/Furazolidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Morphological and radiological findings in induced abnormal bone growth in lambs.
Next Document: Changes in myocardial ultrastructure during development of furazolidone-induced cardiomyopathy in tu...