Document Detail


Quantitative microscopy and systems biology: seeing the whole picture.
MedLine Citation:
PMID:  18830616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding cellular function requires studying the spatially resolved dynamics of protein networks. From the isolated proteins we can only learn about their individual properties, but by investigating their behavior in their natural environment, the cell, we obtain information about the overall response properties of the network module in which they operate. Fluorescence microscopy methods provide currently the only tools to study the dynamics of molecular processes in living cells with high temporal and spatial resolution. Combined with computational approaches they allow us to obtain insights in the reaction-diffusion processes that determine biological function on the scale of cells.
Authors:
Peter J Verveer; Philippe I H Bastiaens
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-10-01
Journal Detail:
Title:  Histochemistry and cell biology     Volume:  130     ISSN:  0948-6143     ISO Abbreviation:  Histochem. Cell Biol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-13     Completed Date:  2008-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506663     Medline TA:  Histochem Cell Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  833-43     Citation Subset:  IM    
Affiliation:
Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany. verveer@mpi-dortmund.mpg.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Image Processing, Computer-Assisted
Intercellular Signaling Peptides and Proteins / metabolism
Membrane Proteins / metabolism
Microscopy, Fluorescence*
Molecular Probe Techniques*
Signal Transduction
Systems Biology*
Time Factors
Chemical
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins

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