| Quantitative microscopy and systems biology: seeing the whole picture. | |
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MedLine Citation:
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PMID: 18830616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding cellular function requires studying the spatially resolved dynamics of protein networks. From the isolated proteins we can only learn about their individual properties, but by investigating their behavior in their natural environment, the cell, we obtain information about the overall response properties of the network module in which they operate. Fluorescence microscopy methods provide currently the only tools to study the dynamics of molecular processes in living cells with high temporal and spatial resolution. Combined with computational approaches they allow us to obtain insights in the reaction-diffusion processes that determine biological function on the scale of cells. |
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Authors:
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Peter J Verveer; Philippe I H Bastiaens |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-10-01 |
Journal Detail:
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Title: Histochemistry and cell biology Volume: 130 ISSN: 0948-6143 ISO Abbreviation: Histochem. Cell Biol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-13 Completed Date: 2008-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506663 Medline TA: Histochem Cell Biol Country: Germany |
Other Details:
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Languages: eng Pagination: 833-43 Citation Subset: IM |
Affiliation:
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Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany. verveer@mpi-dortmund.mpg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Image Processing, Computer-Assisted Intercellular Signaling Peptides and Proteins / metabolism Membrane Proteins / metabolism Microscopy, Fluorescence* Molecular Probe Techniques* Signal Transduction Systems Biology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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