Document Detail


Quantitative microscopy and imaging tools for the mechanical analysis of morphogenesis.
MedLine Citation:
PMID:  21893407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The importance of mechanical signals during embryogenesis and development, through both intercellular and extracellular signals, is coming into focus. It is widely hypothesized that physical forces help to guide the shape, cellular differentiation and the patterning of tissues. To test these ideas many classical engineering principles and imaging technologies are being adapted. Recent advances in microscopy, mechanical testing and genetic and pharmacological techniques, alongside computational models are helping to dissect the activity of mechanical signals in development at the cellular and molecular level. These inroads are providing maps of mechanical changes in tissue structure and stiffness, and will permit deeper insights into the role of mechanics in both developmental biology and disease.
Authors:
Steven M Trier; Lance A Davidson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-09-03
Journal Detail:
Title:  Current opinion in genetics & development     Volume:  21     ISSN:  1879-0380     ISO Abbreviation:  Curr. Opin. Genet. Dev.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-11-01     Completed Date:  2012-03-02     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9111375     Medline TA:  Curr Opin Genet Dev     Country:  England    
Other Details:
Languages:  eng     Pagination:  664-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Bioengineering, University of Pittsburgh, 3501 5th Avenue, Pittsburgh, PA 15213, United States. smt74@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Microscopy / methods*
Models, Biological
Morphogenesis*
Signal Transduction
Grant Support
ID/Acronym/Agency:
R01 HD044750/HD/NICHD NIH HHS; R01-HD044750/HD/NICHD NIH HHS; R21 ES019259/ES/NIEHS NIH HHS; R21-ES019259/ES/NIEHS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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