Document Detail


Quantitative methanol-burning lung model for validating gas-exchange measurements over wide ranges of FIO2.
MedLine Citation:
PMID:  9609815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The methanol-burning lung model has been used as a technique for generating a predictable ratio of carbon dioxide production (VCO2) to oxygen consumption (VO2) or respiratory quotient (RQ). Although an accurate RQ can be generated, quantitatively predictable and adjustable VO2 and VCO2 cannot be generated. We describe a new burner device in which the combustion rate of methanol is always equal to the infusion rate of fuel over an extended range of O2 concentrations. This permits the assembly of a methanol-burning lung model that is usable with O2 concentrations up to 100% and provides continuously adjustable and quantitative VO2 (69-1,525 ml/min) and VCO2 (46-1,016 ml/min) at a RQ of 0.667.
Authors:
S Miodownik; J Melendez; V A Carlon; B Burda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  84     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-07     Completed Date:  1998-07-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2177-82     Citation Subset:  IM; S    
Affiliation:
Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Calorimetry, Indirect
Carbon Dioxide / metabolism
Lung / metabolism*
Methanol / chemistry*
Models, Biological
Oxygen Consumption / physiology*
Pulmonary Gas Exchange / physiology*
Respiratory Function Tests / methods*
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 67-56-1/Methanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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