| Quantitative measurement of regional blood flow with gadolinium diethylenetriaminepentaacetate bolus track NMR imaging in cerebral infarcts in rats: validation with the iodo[14C]antipyrine technique. | |
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MedLine Citation:
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PMID: 7892189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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NMR bolus track measurements were correlated with autoradiographically determined regional cerebral blood flow (rCBF). The NMR method is based on bolus infusion of the contrast agent gadolinium diethylenetriaminepentaacetate and high-speed T*2-sensitive NMR imaging. The first pass of the contrast agent through the image plane causes a transient decrease of the signal intensity. This time course of the signal intensity is transformed into relative concentrations of the contrast agent in each pixel. The mean transit time and relative blood flow and volume are calculated from such indicator dilution curves. We investigated whether this NMR technique correctly expresses the relative rCBF. The relative blood flow data, calculated from NMR bolus track experiments, and the absolute values of iodo[14C]antipyrine autoradiography were compared. A linear relationship was observed, indicating the proportionality of the transient NMR signal change with CBF. Excellent interindividual reproducibility of calibration constants is observed (r = 0.963). For a given NMR protocol, bolus track measurements calibrated with autoradiography after the experiment allow determination of absolute values for rCBF and regional blood volume. |
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Authors:
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F Wittlich; K Kohno; G Mies; D G Norris; M Hoehn-Berlage |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 92 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-20 Completed Date: 1995-04-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1846-50 Citation Subset: IM |
Affiliation:
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Max-Planck-Institut for Neurological Research, Cologne, Federal Republic of Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipyrine / analogs & derivatives*, diagnostic use Blood Pressure Brain / blood supply, pathology* Carbon Dioxide / blood Carbon Radioisotopes / diagnostic use Cerebral Infarction / blood, pathology, physiopathology* Cerebrovascular Circulation* Contrast Media Gadolinium / diagnostic use Gadolinium DTPA Magnetic Resonance Spectroscopy / methods Male Organometallic Compounds / diagnostic use* Oxygen / blood Partial Pressure Pentetic Acid / analogs & derivatives*, diagnostic use Rats Rats, Wistar Regional Blood Flow |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Contrast Media; 0/Organometallic Compounds; 124-38-9/Carbon Dioxide; 129-81-7/iodoantipyrine; 60-80-0/Antipyrine; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 7782-44-7/Oxygen; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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