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Quantitative measurement of mitral valve coaptation in functional mitral regurgitation: In vivo experimental study by real-time three-dimensional echocardiography.
MedLine Citation:
PMID:  19167644     Owner:  NLM     Status:  In-Process    
BACKGROUND: The degree of mitral valve (MV) coaptation should be an important parameter in the assessment of functional mitral regurgitation (MR). This study aimed to quantify the degree of MV coaptation in experimental models of functional MR caused by acute left ventricular (LV) pressure overload, using real-time three-dimensional (3D) echocardiography.
METHODS AND RESULTS: Using canine models, LV pressure overload was induced by staged ascending aortic banding. Echocardiographic examinations were performed before and during the aortic banding. By using a novel software system for 3D quantification (REALVIEW®), the annulus and leaflet were traced manually both at the onset of MV closure and at the maximum MV closure. The coaptation index was calculated by the following formula: [(3D tenting surface area at the onset of MV closure-3D tenting surface area at the maximum MV closure)/3D tenting surface area at the onset of MV closure] x 100. MR area gradually increased with the decrease in coaptation index during progressively exacerbated aortic banding. MR area was significantly correlated with the coaptation index. A coaptation index < 12 had a high sensitivity and specificity in the presence of significant MR.
CONCLUSIONS: The degree of MV coaptation can be quantified using 3D echocardiography. The coaptation index should be a useful parameter in the assessment of functional MR.
Ryotaro Yamada; Nozomi Watanabe; Teruyoshi Kume; Miwako Tsukiji; Takahiro Kawamoto; Yoji Neishi; Akihiro Hayashida; Eiji Toyota; Hiroyuki Okura; Kiyoshi Yoshida
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Publication Detail:
Type:  Journal Article     Date:  2008-11-08
Journal Detail:
Title:  Journal of cardiology     Volume:  53     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  94-101     Citation Subset:  IM    
Department of Cardiology, Kawasaki Medical School, Kurashiki, Japan.
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