| Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer's disease. | |
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MedLine Citation:
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PMID: 16540327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alzheimer's disease (AD) and vascular dementia (VaD) both share significant vascular risk factors. The present study measures the haemodynamics of these diseases in absolute rather than relative terms. Twenty-four patients were classified as either early AD or VaD and were compared with 12 non-cognitively impaired subjects. Magnetic resonance imaging flow quantification was used to measure arterial inflow and arterial pulse volume. Mean vascular resistance and compliance were calculated. In AD, the arterial inflow was lower by 18%, resistance was higher by 23% and compliance of the arterial tree was lower by 20% compared with normal (p=0.01, 0.02 and 0.05, respectively). In VaD, the arterial pulse volume was higher by 24% and compliance was higher by 35% compared with normal (p=0.05 for both). Early VaD is characterized by normal blood flow, but increased pulsation. Reduced blood flow and an incompliant arterial tree characterize early AD. |
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Authors:
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Grant A Bateman; Christopher R Levi; Peter Schofield; Yang Wang; Elizabeth C Lovett |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-15 |
Journal Detail:
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Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: 13 ISSN: 0967-5868 ISO Abbreviation: J Clin Neurosci Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-13 Completed Date: 2006-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: Scotland |
Other Details:
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Languages: eng Pagination: 563-8 Citation Subset: IM |
Affiliation:
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Department of Medical Imaging, John Hunter Hospital, Locked Bag 1, Newcastle Region Mail Center, New South Wales 2310, Australia. grant.bateman@hnehealth.nsw.gov.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis, physiopathology* Brain / blood supply*, pathology Cerebrovascular Circulation / physiology Cohort Studies Dementia, Vascular / diagnosis, physiopathology* Female Humans Magnetic Resonance Imaging / standards* Male Middle Aged Vascular Resistance / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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