Document Detail


Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain.
MedLine Citation:
PMID:  17659567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the relationship of myelin content, axonal density, and gliosis with the fraction of macromolecular protons (fB) and T2 relaxation of the macromolecular pool (T2B) acquired using quantitative magnetization transfer (qMT) MRI in postmortem brains of subjects with multiple sclerosis (MS).
MATERIALS AND METHODS: fB and T2B were acquired in unfixed postmortem brain slices of 20 subjects with MS. The myelin content, axonal count, and severity of gliosis were all quantified histologically. t-Tests and multiple regression were used for analysis.
RESULTS: MR indices obtained in unfixed postmortem MS brains were consistent with in vivo values reported in the literature. A significant correlation was detected between Tr(myelin) (inversely proportional to myelin content) and 1) fB (r = -0.80, P < 0.001) and 2) axonal count (r = -0.79, P < 0.001). fB differed between 1) normal-appearing white matter (NAWM) and remyelinated WM lesions (rWMLs) (mean: fB 6.9 [SD 2] vs. 4.0 [1.8], P = 0.01), and 2) rWMLs and demyelinated WMLs (mean: 4.2 [2.2] vs. 2.5 [1.3], P = 0.016). No association was detected between T2B and any of the histological measures.
CONCLUSION: fB in MS WM is dependent on myelin content and may be a tool to monitor patients with this condition.
Authors:
Klaus Schmierer; Daniel J Tozer; Francesco Scaravilli; Daniel R Altmann; Gareth J Barker; Paul S Tofts; David H Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  26     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-31     Completed Date:  2007-10-18     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  41-51     Citation Subset:  IM    
Copyright Information:
Copyright 2007 Wiley-Liss, Inc.
Affiliation:
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom. k.schmierer@ion.ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Brain / pathology*
Cadaver
Female
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Multiple Sclerosis / pathology*
Myelin Sheath / pathology*
Regression Analysis
Retrospective Studies
Stereotaxic Techniques
Grant Support
ID/Acronym/Agency:
075941//Wellcome Trust; 075941//Wellcome Trust
Comments/Corrections

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