Document Detail


Quantitative magnetic resonance imaging of brain development in premature and mature newborns.
MedLine Citation:
PMID:  9485064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Definition in the living premature infant of the anatomical and temporal characteristics of development of critical brain structures is crucial for insight into the time of greatest vulnerability of such brain structures. We used three-dimensional magnetic resonance imaging (3D MRI) and image-processing algorithms to quantitate total brain volume and total volumes of cerebral gray matter (GM), unmyelinated white matter (WM), myelinated WM, and cerebrospinal fluid (CSF) in 78 premature and mature newborns (postconceptional age, 29-41 weeks). Total brain tissue volume was shown to increase linearly at a rate of 22 ml/wk. Total GM showed a linear increase in relative intracranial volume of approximately 1.4% or 15 ml in absolute volume per week. The pronounced increase in total GM reflected primarily a fourfold increase in cortical GM. Unmyelinated WM was found to be the most prominent brain tissue class in the preterm infant younger than 36 weeks of postconceptional age. Although minimal myelinated WM was present in the preterm infant at 29 weeks, between 35 and 41 weeks an abrupt fivefold increase in absolute volume of myelinated WM was documented. Extracerebral and intraventricular CSF was readily quantitated by this technique and found to change minimally. The application of 3D MRI and tissue segmentation to the study of human infant brain from 29 to 41 weeks of postconceptional age has provided new insights into cerebral cortical development and myelination and has for the first time provided means of quantitative assessment in vivo of early human brain development.
Authors:
P S Hüppi; S Warfield; R Kikinis; P D Barnes; G P Zientara; F A Jolesz; M K Tsuji; J J Volpe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  43     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-03     Completed Date:  1998-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-35     Citation Subset:  IM    
Affiliation:
Joint Program in Neonatology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Body Composition
Brain / anatomy & histology,  growth & development*
Cerebrospinal Fluid
Female
Humans
Image Processing, Computer-Assisted
Infant, Newborn*
Infant, Premature*
Magnetic Resonance Imaging*
Male
Parity
Prospective Studies
Reference Values

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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