| Quantitative magnetic resonance fluorine imaging: today and tomorrow. | |
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MedLine Citation:
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PMID: 20564465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fluorine (19F) is a promising moiety for quantitative magnetic resonance imaging (MRI). It possesses comparable magnetic resonance (MR) sensitivity to proton (1H) but exhibits no tissue background signal, allowing specific and selective assessment of the administrated 19F-containing compounds in vivo. Additionally, the MR spectra of 19F-containing compounds exhibited a wide range of chemical shifts (>200 ppm). Therefore, both MR parameters (e.g., spin-lattice relaxation rate R1) and the absolute quantity of molecule can be determined with 19F MRI for unbiased assessment of tissue physiology and pathology. This article reviews quantitative 19F MRI applications for mapping tumor oxygenation, assessing molecular expression in vascular diseases, and tracking labeled stem cells. |
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Authors:
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Junjie Chen; Gregory M Lanza; Samuel A Wickline |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology Volume: 2 ISSN: 1939-0041 ISO Abbreviation: Wiley Interdiscip Rev Nanomed Nanobiotechnol Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-09-15 Revised Date: 2011-01-14 |
Medline Journal Info:
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Nlm Unique ID: 101508311 Medline TA: Wiley Interdiscip Rev Nanomed Nanobiotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 431-40 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 John Wiley & Sons, Inc. |
Affiliation:
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Consortium for Translational Research in Advanced Imaging and Nanomedicine, St Louis, MO 63108, USA. junjie@dom.wustl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Hypoxia Fluorine / diagnostic use* Fluorocarbons / diagnostic use* Magnetic Resonance Imaging / methods* Mice Neoplasms / diagnosis, metabolism Whole Body Imaging / methods |
| Chemical | |
Reg. No./Substance:
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0/Fluorocarbons; 7782-41-4/Fluorine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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