| Quantitative investigation of solitary pulmonary nodules: dynamic contrast-enhanced MRI and histopathologic analysis. | |
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MedLine Citation:
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PMID: 18562755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purposes of this study were to analyze the relation between enhancement patterns on dynamic enhanced MRI and histologic microvessel patterns of solitary pulmonary nodules (SPNs) and to address the topic of false-positive findings in differentiating SPNs with dynamic MRI. SUBJECTS AND METHODS: Sixty-eight patients with 68 pathologically proven SPNs (diameter <or= 30 mm) underwent dynamic 1.5-T MRI. On time-signal intensity curves generated after bolus injection of contrast material, steepest slope, peak height, and enhancement ratios of signal intensity at the first, second, and fourth minutes were calculated. The relation between dynamic MRI values and microvessel density was analyzed. The morphologic differences between malignant SPNs and active inflammatory SPNs also were analyzed. Threshold dynamic MRI values for differential diagnosis were determined. RESULTS: The dynamic MRI values of benign SPNs were significantly lower than those of the other SPNs (p < 0.01). The enhancement ratio at the fourth minute for active inflammatory SPNs was significantly higher than that of malignant SPNs (p < 0.01). A high correlation coefficient (r = 0.87, p < 0.001) was found between steepest slope and microvessel density. With steepest slope 1.5%/s or less, benign SPNs were clearly differentiated from other SPNs. With enhancement ratio at the fourth minute 65% or less, malignant SPNs were differentiated from active inflammatory SPNs with high sensitivity (93%) and high specificity (100%). CONCLUSION: Dynamic MRI values reflect the quantitative and morphologic characteristics of microvessels in SPNs and are a useful tool for differentiating SPNs with little overlap. |
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Authors:
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Yu Zou; Minming Zhang; Qidong Wang; Desheng Shang; Lijun Wang; Guowei Yu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 191 ISSN: 1546-3141 ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-19 Completed Date: 2008-07-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 252-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qinchun Rd., Hangzhou, Zhejiang Province 310003, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Contrast Media False Positive Reactions Female Gadolinium DTPA / diagnostic use* Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Lung Neoplasms / radionuclide imaging* Male Middle Aged Reproducibility of Results Sensitivity and Specificity Solitary Pulmonary Nodule / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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