| Quantitative insulin and C-peptide levels among ED patients with sulfonylurea-induced hypoglycemia-a prospective case series. | |
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MedLine Citation:
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PMID: 20887914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to measure the serum insulin and C-peptide concentrations among diabetic patients known to be taking sulfonylurea agents who presented to the emergency department with hypoglycemia thought to be due to therapeutic usage as opposed to overdose. A recently published systematic review of 22 articles involving 76 patients with sulfonylurea-induced hypoglycemia (glucose <49 mg/dL) resulting from accidental ingestion or intentional overdose found that patients had an average serum insulin concentration of 3.9 μIU/mL or higher and an average serum C-peptide concentration of 1.4 ng/mL or higher. METHODS: This is a prospective cross-sectional descriptive case series. RESULTS: Thirteen of 14 study subjects had initial insulin and C-peptide levels consistent with the diagnosis of sulfonylurea-induced hypoglycemia as previously defined among patients presenting after overdose. CONCLUSION: Patients presenting with hypoglycemia resulting from therapeutic sulfonylurea use demonstrate similar insulin and C-peptide levels as has previously been published among patients who presented with presumed overdose. |
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Authors:
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Charles J Fasano; Adam K Rowden; Gerald F O'Malley; Elizabeth Aguilera; Kennon Heard |
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Publication Detail:
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Type: Journal Article Date: 2010-03-25 |
Journal Detail:
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Title: The American journal of emergency medicine Volume: 28 ISSN: 1532-8171 ISO Abbreviation: Am J Emerg Med Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-25 Revised Date: 2011-10-05 |
Medline Journal Info:
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Nlm Unique ID: 8309942 Medline TA: Am J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 952-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Emergency Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA. fasanoc@einstein.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over C-Peptide / blood* Cross-Sectional Studies Female Glipizide / adverse effects Glyburide / adverse effects Humans Hypoglycemia / blood, chemically induced* Hypoglycemic Agents / adverse effects* Insulin / blood* Male Middle Aged Overdose / blood Prospective Studies Sulfonylurea Compounds / adverse effects* |
| Grant Support | |
ID/Acronym/Agency:
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K08 DA020573-03/DA/NIDA NIH HHS; K08 DA020573-04/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/C-Peptide; 0/Hypoglycemic Agents; 0/Sulfonylurea Compounds; 10238-21-8/Glyburide; 11061-68-0/Insulin; 29094-61-9/Glipizide |
| Comments/Corrections | |
Comment In:
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Am J Emerg Med. 2011 Sep;29(7):812-3
[PMID:
21872103
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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