| Quantitative in-line monitoring of solvent-mediated polymorphic transformation of sulfamerazine by near-infrared spectroscopy. | |
| | |
MedLine Citation:
|
PMID: 22234855 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The in-line monitoring of pharmaceutical processes with high risk, such as crystallization, has been one of the most popular research topics in recent years. Sulfamerazine (SMZ), a well-known sulfonamide antibacterial agent was investigated to examine the mechanism of polymorphic conversion by solvent-mediated polymorphic transformation (SMPT). The primary purpose of this study is to monitor the polymorphic transformation through in-line near-infrared (NIR) measurements and concurrently interpret the whole process quantitatively with off-line characterizations. Samples taken at every hour during SMPT were analyzed by X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). NIR spectra in the range of 7500-4900 cm(-1) were taken into account for multivariate analysis, which included partial least square (PLS) regression and principal component analysis (PCA). In brief, the form II content was estimated very accurately and reproducibly during the SMPT process not only by XRD but also by the DSC measurements. In addition, the form II content values were predicted very accurately by separate experiments at two designated time points. In a separate study, it was demonstrated that PCA could be employed to explain a complicated process such as SMPT mechanistically by several stages. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci. |
| | |
Authors:
|
Min-Jeong Lee; Da-Young Seo; In-Chun Wang; Nan-Hee Chun; Hea-Eun Lee; Myung-Yung Jeong; Woo-Sik Kim; Guang J Choi |
Related Documents
:
|
21693795 - Multivariate classification of systemic vascular resistance using photoplethysmography. 22437185 - The role of physical barriers in the location of avian suture zones in the guiana shiel... 21780705 - Non-isothermal modelling of h2s removal in a biofilter. 21566255 - Robust feature selection for microarray data based on multicriterion fusion. 11950135 - Genetic and environmental adaptation in high altitude natives. conceptual, methodologic... 17714275 - Positive effects of helpers on reproductive success in the brown treecreeper and the ge... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
|
Title: Journal of pharmaceutical sciences Volume: - ISSN: 1520-6017 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Smart Foods and Drugs, Inje University, Gimhae, Gyeongnam 621-749, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Human umbilical cord Wharton's jelly mesenchymal stem cells do not transform to tumor-associated fib...
Next Document: "Point" centromeres of Saccharomyces harbor single centromere-specific nucleosomes.