Document Detail

Quantitative impact of cardiovascular risk factors and vascular closure devices on the femoral artery after repeat cardiac catheterization.
MedLine Citation:
PMID:  20102878     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We evaluated the exact quantitative long-term impact of repeated catheterizations, vascular closure devices, and cardiovascular risk factors on the femoral artery after cardiac catheterization.
METHODS: A total of 2,102 available femoral angiograms from 827 consecutive patients were analyzed using caliper-based quantitative vascular analysis. These patients underwent coronary interventions between January 2005 and April 2007 and had at least one additional catheterization procedure through the ipsilateral femoral access site from December 2001 until January 2008. Multivariate analysis was performed to control for confounding variables. The primary outcome was change in artery size.
RESULTS: The average punctured artery diameter was 6.5 +/- 2.1 mm. The average time between the first case and last follow-up was 349 days. There was no significant change of the punctured artery size over time after the index procedure (P = .15) and no change associated with the use of vascular closure devices (P = .25) after multivariate analysis. Smaller arteries were associated with female gender (-1.22 mm, P < .0001), presence of angiographic peripheral vascular disease (PVD, -1.19 mm, P < .0001), and current (-0.48 mm, P = .001) or former (-0.23 mm, P = .01) smoking status, whereas previous statin therapy was associated with an increase in artery size (+0.47 mm, P < .0001). Vascular closure devices were used less often compared with manual compression in cases preceding the first detection of angiographic PVD (P < .001).
CONCLUSION: Vascular closure devices are not associated with a change in the artery size or progression of PVD. Overall, there is no change in vessel size over time after repeat catheterizations, with a decrease in vessel size associated with current and former smoking and an increase with previous statin therapy.
Klaus A Tiroch; Michael E Matheny; Frederic S Resnic
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  159     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-03-02     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-30     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
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MeSH Terms
Angiography / methods
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation,  methods
Cardiac Catheterization / adverse effects*,  instrumentation*
Cohort Studies
Coronary Disease / radiography,  therapy*
Equipment Design
Equipment Safety
Evaluation Studies as Topic
Femoral Artery*
Follow-Up Studies
Hemostatic Techniques / instrumentation
Multivariate Analysis
Peripheral Vascular Diseases / epidemiology,  etiology*,  physiopathology
Risk Factors
Treatment Outcome
Grant Support
R01 LM008142/LM/NLM NIH HHS; R01 LM008142-06/LM/NLM NIH HHS

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