Document Detail

Quantitative immunohistochemistry of immunoglobulin- and J-chain-producing cells in human parotid and submandibular salivary glands.
MedLine Citation:
PMID:  6769784     Owner:  NLM     Status:  MEDLINE    
Ig-producing cells were quantified by paired immunohistochemical staining in saline-extracted and paraffin-embedded normal tissue specimens from human parotid (ten) and submandibular (seven) salivary glands. The density of such cells (number/mm2 of 6 micron thick tissue section) was significantly higher in the submandibular than in the parotid gland (P less than 0.005), but the Ig-class distribution was fairly similar. The mean percentage class ratios for IgG, IgA, IgM and IgD cells in the parotid were 4.5:86.5:5.9:3.1, and in the submandibular gland 3.7:86.9:7.9:1.6. In the parotid gland of a patient with selective IgA deficiency the same class ratios were 27:0:20:53. Thus, the IgA cells were especially replaced by IgD cells. In normal glands most of the IgA (80-93%), IgM (99-100%) and IgD cells (81-95%) were J-chain-positive; this was likewise true for a substantial proportion of the IgG cells (32-46%). Of additional interest was the finding that in the IgA-deficient parotid gland, 99% of the numerous IgD cells and 86% of the increased number of IgG cells contained cytoplasmic J chain. IgE-producing cells were virtually absent from the IgA-deficient as well as from the normal salivary glands.
F R Korsrud; P Brandtzaeg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunology     Volume:  39     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-40     Citation Subset:  IM    
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MeSH Terms
Antibody-Producing Cells
Dysgammaglobulinemia / immunology
Fluorescent Antibody Technique
Immunoglobulin A
Immunoglobulin J-Chains / analysis*
Immunoglobulins / analysis*
Middle Aged
Parotid Gland / immunology*
Submandibular Gland / immunology*
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin J-Chains; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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