Document Detail


Quantitative immunohistochemistry of immunoglobulin- and J-chain-producing cells in human parotid and submandibular salivary glands.
MedLine Citation:
PMID:  6769784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ig-producing cells were quantified by paired immunohistochemical staining in saline-extracted and paraffin-embedded normal tissue specimens from human parotid (ten) and submandibular (seven) salivary glands. The density of such cells (number/mm2 of 6 micron thick tissue section) was significantly higher in the submandibular than in the parotid gland (P less than 0.005), but the Ig-class distribution was fairly similar. The mean percentage class ratios for IgG, IgA, IgM and IgD cells in the parotid were 4.5:86.5:5.9:3.1, and in the submandibular gland 3.7:86.9:7.9:1.6. In the parotid gland of a patient with selective IgA deficiency the same class ratios were 27:0:20:53. Thus, the IgA cells were especially replaced by IgD cells. In normal glands most of the IgA (80-93%), IgM (99-100%) and IgD cells (81-95%) were J-chain-positive; this was likewise true for a substantial proportion of the IgG cells (32-46%). Of additional interest was the finding that in the IgA-deficient parotid gland, 99% of the numerous IgD cells and 86% of the increased number of IgG cells contained cytoplasmic J chain. IgE-producing cells were virtually absent from the IgA-deficient as well as from the normal salivary glands.
Authors:
F R Korsrud; P Brandtzaeg
Related Documents :
20504704 - Influence of cytoplasmic atp reduction on catecholamine synthesis in cultured bovine ad...
2146004 - Norepinephrine suppresses both photoreceptor and neuron-like properties expressed by cu...
6307394 - Glucocorticoid control of steroidogenesis in isolated rat adrenocortical cells.
20200334 - Adrenocortical zonation in humans under normal and pathological conditions.
6425024 - Cell sorting and microchemistry of cultured human fibroblasts: applications in genetics...
12609024 - Re-organisation of the cytoskeleton during developmental programmed cell death in picea...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunology     Volume:  39     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibody-Producing Cells
Dysgammaglobulinemia / immunology
Female
Fluorescent Antibody Technique
Humans
Immunoglobulin A
Immunoglobulin J-Chains / analysis*
Immunoglobulins / analysis*
Male
Middle Aged
Parotid Gland / immunology*
Submandibular Gland / immunology*
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin J-Chains; 0/Immunoglobulins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The establishment of continuous macrophage cell lines from peripheal blood monocytes.
Next Document:  Studies of the transport of polyclonal IgA antibody from blood to bile in rats.