| Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA). | |
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MedLine Citation:
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PMID: 17654593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MRI-based cartilage morphometry was previously validated in the absence of gadopentate dimeglumine (Gd-DTPA). However, Gd-DTPA is required for compositional (proteoglycan) imaging using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Therefore, the effect of Gd-DTPA on cartilage morphometry was studied. A total of 165 female participants (67 with and 98 without osteoarthritis [OA]) were imaged at 3.0 Tesla before and 2 hr after intravenous Gd-DTPA injection. Flip angles in post-Gd-DTPA scans varied between 12 degrees and 35 degrees . Cartilage volume and thickness of post- vs. pre-Gd-DTPA scans showed intraclass correlation coefficients (ICCs) of 0.85 > or = r > or = 0.95, mean differences between -2.1% and +1.1%, and standard deviations (SDs) of differences between 4.7% and 9.2%. Mixed-effect models found no consistent impact of flip angle and OA status on post- vs. pre-Gd-DTPA differences. Accurate morphological measurements of cartilage can be obtained after Gd-DTPA injection, allowing compositional and morphological imaging to be combined into one session. |
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Authors:
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Felix Eckstein; Robert J Buck; Bradley T Wyman; John J Kotyk; Marie-Pierre Hellio Le Graverand; Ann E Remmers; Jeffrey L Evelhoch; Martin Hudelmaier; H Cecil Charles |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 58 ISSN: 0740-3194 ISO Abbreviation: Magn Reson Med Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-30 Completed Date: 2007-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 402-6 Citation Subset: IM |
Affiliation:
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Institute of Anatomy and Musculoskeletal Research, Paracelsus Private University, Salzburg, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cartilage, Articular / pathology* Contrast Media Cross-Sectional Studies Female Gadolinium DTPA / administration & dosage* Humans Image Processing, Computer-Assisted Injections, Intravenous Magnetic Resonance Imaging / methods* Middle Aged Osteoarthritis, Knee / pathology* Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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