Document Detail

Quantitative genetic variation of esterase activity associated with a gene amplification in Culex quinquefasciatus.
MedLine Citation:
PMID:  2061094     Owner:  NLM     Status:  MEDLINE    
Amplification of the esterase B1 gene is responsible for insecticide resistance in the mosquito Culex quinquefasciatus. We used a mating scheme to isolate chromosomes carrying amplified esterase genes from a long-selected laboratory strain (Tem-R) to determine whether observed variation in esterase activity had a genetic basis. The amplified esterase genes segregated as a block and a possible newly arisen esterase B1 copy-number variant was found among the progeny of females which carried amplified B1 genes on only one homologue. A quantitative genetic analysis found significant genetic variation of esterase activity among families which carried different amplification-bearing chromosomes from the Tem-R strain. Esterase B1 copy-number variation among these Tem-R chromosomes is the most likely basis for the observed genetic variation in esterase activity.
J A Ferrari; G P Georghiou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Heredity     Volume:  66 ( Pt 2)     ISSN:  0018-067X     ISO Abbreviation:  Heredity     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-06     Completed Date:  1991-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
Department of Biology, California State University, San Bernadino 92407.
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MeSH Terms
Analysis of Variance
Crosses, Genetic
Culex / genetics*
Gene Amplification
Insecticide Resistance / genetics
Multigene Family*
Proteins / analysis
Regression Analysis
Sex Factors
Reg. No./Substance:

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