Document Detail

Quantitative gated blood pool SPECT for the assessment of coronary artery disease at rest.
MedLine Citation:
PMID:  9869478     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Planar gated blood pool imaging (GBPI) has long proven to be useful for the noninvasive assessment of ventricular function. From a practical viewpoint, gated blood pool single photon emission computed tomography (GBPS) acquisition can be accomplished in the same time as a three-view planar series, with the benefit of a tomographic perspective that avoids chamber overlap. METHODS AND RESULTS: Quantitative gated blood pool SPECT was applied to 10 patients who underwent coronary arteriography, contrast ventriculography, and planar gated blood pool imaging. For each patient, the mid-short axis oblique slice was divided into 4 discrete segments using 4 different reference models and 2 forms of segmentation. A center of mass (counts) fixed in the end-diastolic frame and segmentation that bisected the ventricular septum proved to have the highest sensitivity and specificity for determining regional wall motion abnormalities at rest in myocardium supplied by severely diseased coronary arteries (>75 %). GBPS correctly identified 19 of 21 abnormal segments (90%), with good specificity (95%), whereas ventriculography identified 12 (57%) and planar GBPI identified 9 (43%) of the segments supplied by diseased coronaries. CONCLUSION: Quantitative GBPS appears to be a sensitive method for assessing coronary artery disease at rest in myocardium perfused by severely diseased coronary arteries.
M W Groch; R C Marshall; W D Erwin; D J Schippers; C A Barnett; E M Leidholdt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  5     ISSN:  1071-3581     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-03-03     Completed Date:  1999-03-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  567-73     Citation Subset:  IM    
Northwestern University School of Medicine, Chicago, IL, USA.
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MeSH Terms
Coronary Disease / physiopathology,  radionuclide imaging*
Gated Blood-Pool Imaging*
Heart Catheterization
Middle Aged
Myocardial Contraction
Sensitivity and Specificity
Stroke Volume
Tomography, Emission-Computed, Single-Photon*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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