Document Detail

Quantitative first-pass perfusion MRI of the mouse myocardium.
MedLine Citation:
PMID:  22907879     Owner:  NLM     Status:  Publisher    
In this article, we present a first-pass perfusion imaging protocol to determine quantitative regional perfusion values (in mL min(-1)  g(-1) ) of the mouse myocardium. Perfusion was quantified using a Fermi-constrained deconvolution of the myocardial tissue response with the arterial input function. A dual-bolus approach was implemented. Experimental evidence is presented for the linearity of signal intensity in the left-ventricular lumen during the prebolus (r = 0.99, P < 0.001) and in the myocardium during the full-bolus injection (r = 0.99, P < 0.01) as function of Gd(DTPA)(2-) injection concentration used. The prebolus was used to reconstruct a nonsaturated arterial input function. Regional perfusion values proved repeatable in a cohort of nine healthy C57BL/6 mice. The perfusion values over two measurements with a 1-week interval were 7.3 ± 0.9 and 7.2 ± 0.6 mL min(-1)  g(-1) , respectively. No effects of time (P > 0.05) and myocardial region (P > 0.05) were observed. The between-session coefficient of variation was only 6%, whereas the inter-animal coefficient of variation was 11 and 8% for the separate experiments. We expect that the first-pass perfusion method here presented will be useful in preclinical studies of myocardial perfusion deficits and valuable to assess the impact of pro-angiogenic therapy after myocardial infarction. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.
Bastiaan J van Nierop; Bram F Coolen; Wouter J R Dijk; Arjan D Hendriks; Larry de Graaf; Klaas Nicolay; Gustav J Strijkers
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands.
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