| Quantitative first-pass perfusion MRI of the mouse myocardium. | |
| | |
MedLine Citation:
|
PMID: 22907879 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In this article, we present a first-pass perfusion imaging protocol to determine quantitative regional perfusion values (in mL min(-1) g(-1) ) of the mouse myocardium. Perfusion was quantified using a Fermi-constrained deconvolution of the myocardial tissue response with the arterial input function. A dual-bolus approach was implemented. Experimental evidence is presented for the linearity of signal intensity in the left-ventricular lumen during the prebolus (r = 0.99, P < 0.001) and in the myocardium during the full-bolus injection (r = 0.99, P < 0.01) as function of Gd(DTPA)(2-) injection concentration used. The prebolus was used to reconstruct a nonsaturated arterial input function. Regional perfusion values proved repeatable in a cohort of nine healthy C57BL/6 mice. The perfusion values over two measurements with a 1-week interval were 7.3 ± 0.9 and 7.2 ± 0.6 mL min(-1) g(-1) , respectively. No effects of time (P > 0.05) and myocardial region (P > 0.05) were observed. The between-session coefficient of variation was only 6%, whereas the inter-animal coefficient of variation was 11 and 8% for the separate experiments. We expect that the first-pass perfusion method here presented will be useful in preclinical studies of myocardial perfusion deficits and valuable to assess the impact of pro-angiogenic therapy after myocardial infarction. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc. |
| | |
Authors:
|
Bastiaan J van Nierop; Bram F Coolen; Wouter J R Dijk; Arjan D Hendriks; Larry de Graaf; Klaas Nicolay; Gustav J Strijkers |
Related Documents
:
|
19327429 - Effect of the wenchuan earthquake in china on hemodynamically unstable ventricular tach... 1739359 - Identification of severe coronary artery disease using simple clinical parameters. 9286939 - Electron beam computed tomographic coronary calcium as a predictor of coronary events: ... 16254679 - Noninvasive detection of coronary artery disease -- challenges for prevention of diseas... 16572959 - Prognostic value of 99mtc-sestamibi stress myocardial perfusion single photon emission ... 22634739 - Quantitative cardiovascular magnetic resonance perfusion imaging: inter-study reproduci... 3967509 - Hemodynamic and oxygen transport patterns in surviving and nonsurviving postoperative p... 3038369 - Denervation supersensitivity of refractoriness in noninfarcted areas apical to transmur... 15596959 - Catheter ablation of monomorphic ventricular tachycardia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-20 |
Journal Detail:
|
Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands. b.j.v.nierop@tue.nl. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improved Air-Stable Solid Aromatic and Heterocyclic Zinc Reagents by Highly Selective Metalations fo...
Next Document: On-line ionic liquid-based dynamic microwave-assisted extraction-high performance liquid chromatogra...