Document Detail


Quantitative fecal lactoferrin in toxin-positive and toxin-negative Clostridium difficile specimens.
MedLine Citation:
PMID:  23135940     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative fecal lactoferrin was measured in 112 patients tested for toxigenic Clostridium difficile using glutamate dehydrogenase (GDH) and toxin immunoassays combined with tcdB PCR. Lactoferrin levels were higher in the GDH-positive/toxin-positive group (79 μg/ml) than in the GDH-positive/toxin-negative/PCR-positive (21 μg/ml) and the GDH-negative groups (13 μg/ml). Differences in fecal lactoferrin levels suggest variable presence or severity of C. difficile infection among toxin-positive and toxin-negative patients.
Authors:
P Rocco LaSala; Tariq Ekhmimi; A Kate Hill; Imran Farooqi; Peter L Perrotta
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2012-11-07
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  51     ISSN:  1098-660X     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-27     Completed Date:  2013-05-29     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-3     Citation Subset:  IM    
Affiliation:
Department of Pathology, Robert C. Byrd Health Sciences Center, West Virginia University, and Clinical Laboratory, West Virginia University Healthcare, Morgantown, West Virginia, USA. plasala@hsc.wvu.edu
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MeSH Terms
Descriptor/Qualifier:
Bacterial Proteins / genetics
Bacterial Toxins / genetics
Clostridium Infections / diagnosis*
Clostridium difficile / genetics,  isolation & purification,  pathogenicity*
Feces / chemistry*
Glutamate Dehydrogenase / analysis
Humans
Immunoassay
Lactoferrin / analysis*
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Bacterial Toxins; 0/LTF protein, human; 0/toxB protein, Clostridium difficile; EC 1.4.1.2/Glutamate Dehydrogenase; EC 3.4.21.-/Lactoferrin
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