Document Detail

Quantitative evaluation of the pyramidal tract segmented by diffusion tensor tractography: feasibility study in patients with amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  15940067     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Diffusion tensor imaging can evaluate the cerebral white matter quantitatively using fractional anisotropy (FA) and also can extract a certain tract by tractography, but these two have been used separately and not combined. The purpose of this study was to assess the clinical feasibility of ROI analysis using diffusion tensor tractography (DTT) in patients with amyotrophic lateral sclerosis (ALS). MATERIALS AND METHODS: Sixteen patients with ALS (9 limb-onset type, 7 bulbar-onset type) and nine age-matched volunteers were studied. DTT of the corticobulbar tract (DTT-CBT) and corticospinal tract (DTT-CST) were visualized by free software (dTV/VOLUME-ONE). Regions-of-interest (ROIs) were semi-automatically placed on the tracts defined by DTT methods, and FA values within the ROIs were measured. RESULTS: Mean FA values of ALS patients in the ROIs along the DTT-CST (bulbar-onset: 0.574, limb-onset: 0.594) were significantly lower than those of controls (DTT-CST: 0.629) (p<0.05). The mean FA of DTT-CBT of the bulbar-onset type (0.509) was significantly lower than that of the limb-onset type (0.558) and that of volunteers (0.561). CONCLUSION: DTT could segmentate certain white matter tracts and evaluate them quantitatively. It could depict the subtle changes between subtypes of ALS as well as the changes between the patients and volunteers.
Shigeki Aoki; Nobue K Iwata; Yoshitaka Masutani; Mariko Yoshida; Osamu Abe; Yoshikazu Ugawa; Tomohiko Masumoto; Harushi Mori; Naoto Hayashi; Hiroyuki Kabasawa; Shin Kwak; Seizou Takahashi; Shoji Tsuji; Kuni Ohtomo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation medicine     Volume:  23     ISSN:  0288-2043     ISO Abbreviation:  Radiat Med     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-07     Completed Date:  2005-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8412264     Medline TA:  Radiat Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Department of Radiology, University of Tokyo Hospital, Tokyo 113-8655, Japan.
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MeSH Terms
Amyotrophic Lateral Sclerosis / pathology*
Brain Mapping / methods
Case-Control Studies
Diffusion Magnetic Resonance Imaging / methods*
Feasibility Studies
Middle Aged
Pyramidal Tracts / pathology*

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