| Quantitative evaluation of ocular surface inflammation in patients with different grade of conjunctivochalasis. | |
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MedLine Citation:
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PMID: 20673042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate and compare HLA-DR expression of conjunctival epithelial cells in different grade of conjunctivochalasis (CCh). Patients and METHODS: Thirty patients and seven healthy subjects underwent clinical examination, grading of CCh by lid-parallel conjunctival fold (LIPCOF) test, and impression cytology of the bulbar conjunctiva. HLA-DR expression was analyzed by flow cytometry. Schirmer test, tear break-up time, and vital staining were also performed. RESULTS: Patients who presented with mild and moderate CCh showed a similar expression of HLA-DR to normal subjects. A significant increase (p < 0.005) of HLA-DR was found in patients with severe CCh. Positive correlation was found between fluorescein staining and HLA-DR expression (r = 0.36, p = 0.009) and between lissamine-green staining and HLA-DR expression (r = 0.30, p = 0.027). Neither correlation was found between Schirmer test nor break up time and HLA-DR expression. CONCLUSION: Inflammation plays a pivotal role on the ocular surface of patients with severe CCh. Since mild and moderate CCh HLA-DR expression was similar to normal controls, we can speculate that the source of inflammation could be the presence of conjunctival folds. |
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Authors:
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Eszter Fodor; Stefano Barabino; Elisa Montaldo; Maria Cristina Mingari; Maurizio Rolando |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current eye research Volume: 35 ISSN: 1460-2202 ISO Abbreviation: Curr. Eye Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: England |
Other Details:
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Languages: eng Pagination: 665-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Semmelweis University, Budapest, Hungary. fodoreszterdr@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism Coloring Agents / metabolism Conjunctiva / metabolism*, pathology Conjunctival Diseases / classification, metabolism*, pathology Epithelial Cells / metabolism*, pathology Female Flow Cytometry HLA-DR Antigens / metabolism* Humans Inflammation / metabolism Lissamine Green Dyes / metabolism Male Middle Aged Staining and Labeling |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Coloring Agents; 0/HLA-DR Antigens; 0/Lissamine Green Dyes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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