| Quantitative evaluation of mean transit times obtained with dynamic susceptibility contrast-enhanced MR imaging and with (133)Xe SPECT in occlusive cerebrovascular disease. | |
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MedLine Citation:
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PMID: 12076942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We report on quantitative mean transit time images obtained using dynamic susceptibility contrast-enhanced MR imaging after an IV bolus injection of a contrast agent. Our study compared cerebral hemodynamics measured using dynamic susceptibility contrast-enhanced MR imaging with the cerebral perfusion reserve obtained using dynamic (133)Xe single-photon emission computed tomography (SPECT). SUBJECTS AND METHODS: Seventeen patients with chronic cerebral artery occlusion or stenosis diagnosed by digital subtraction angiography were examined. Dynamic susceptibility contrast-enhanced MR imaging data were acquired using a multishot echoplanar sequence. Our procedure for quantification of mean transit time was based on the indicator dilution theory and deconvolution analysis. RESULTS: The increased mean transit time values obtained with dynamic susceptibility contrast-enhanced MR imaging correlated well (r=-0.789, p < 0.0001) with decreased cerebral perfusion reserve determined by performing dynamic (133)Xe SPECT before and after administration of acetazolamide. The mean transit time values in the regions with severely decreased perfusion reserve were significantly higher than those in the regions with normal or moderately decreased perfusion reserve (p < 0.0001 and p = 0.0004, respectively). CONCLUSION: Mean transit time images generated from dynamic susceptibility contrast-enhanced MR imaging data could be used to evaluate the extent of cerebral perfusion reserve impairment in patients with occlusive cerebrovascular disease. |
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Authors:
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Keiichi Kikuchi; Kenya Murase; Hitoshi Miki; Yoshifumi Yasuhara; Yoshifumi Sugawara; Teruhito Mochizuki; Junpei Ikezoe; Shiro Ohue |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: AJR. American journal of roentgenology Volume: 179 ISSN: 0361-803X ISO Abbreviation: AJR Am J Roentgenol Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-06-21 Completed Date: 2002-07-12 Revised Date: 2008-02-15 |
Medline Journal Info:
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Nlm Unique ID: 7708173 Medline TA: AJR Am J Roentgenol Country: United States |
Other Details:
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Languages: eng Pagination: 229-35 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime, 791-0295 Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Flow Velocity / physiology Cerebral Arteries / pathology, physiopathology, radionuclide imaging Cerebrovascular Circulation / physiology* Cerebrovascular Disorders / pathology*, physiopathology, radionuclide imaging* Contrast Media* Female Humans Magnetic Resonance Imaging* Male Middle Aged Time Factors Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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