Document Detail

Quantitative evaluation of magnetic resonance imaging (MRI) abnormalities in subclinical hepatic encephalopathy.
MedLine Citation:
PMID:  15783031     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Cirrhotic patients often demonstrate high signal intensity on T1-weighted magnetic resonance (MRI) images in basal ganglia with accumulation of manganese being the predominant causing factor. In these patients, electrophysiological tests and especially electroencephalogram (EEG) are considered to be the most sensitive methods in detection of subclinical hepatic encephalopathy. The aim of this study is to correlate MRI findings with biochemical parameters and EEG alterations in cirrhotic patients without clinically overt encephalopathy. METHODOLOGY: Twenty-two cirrhotic patients (16 males and 6 females, mean age of 65.2 +/- 9.5 years), classified according to Child-Pugh score, were submitted to brain MRI, neurological assessment (including psychometric tests and EEG) and complete biochemical testing. None of them had any clinical signs of brain dysfunction. MRI findings were evaluated both qualitatively (normal, mild, moderate and severe) and quantitatively with the ROI method. EEG alterations were also classified as normal, mild, moderate and severe. RESULTS: Statistical analysis revealed a significant linear association between EEG grading and MRI signal intensity (r2=0.248, p=0.035). Among clinical and biochemical parameters, overall Child-Pugh score and albumin levels were identified as significant predictors of the MRI signal intensity (p=0.006 and p=0.021 respectively). CONCLUSIONS: Although further investigation must be performed to confirm the clinical impact of brain MRI in hepatic cirrhosis, our study strongly suggests that MRI alterations are good predictors of liver and brain dysfunction in cirrhotic patients.
E Solomou; D Velissaris; P Polychronopoulos; A Kalogeropoulos; M Kiriakopoulou; F Mpadra; Th Kordonouri; Ch Karantza
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  52     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-03-23     Completed Date:  2005-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Department of Radiology, University Hospital of Patras, Rio, Greece.
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MeSH Terms
Bilirubin / blood
Brain / pathology*,  physiopathology
Hepatic Encephalopathy / blood,  pathology,  physiopathology
Liver Cirrhosis / blood,  pathology*,  physiopathology
Liver Function Tests
Magnetic Resonance Imaging
Middle Aged
Prothrombin Time
Serum Albumin / metabolism
Severity of Illness Index
Transaminases / blood
Reg. No./Substance:
0/Serum Albumin; 635-65-4/Bilirubin; EC 2.6.1.-/Transaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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