Document Detail

Quantitative evaluation of human placental aromatase in abnormal pregnancy--anencephalus and hydatidiform mole.
MedLine Citation:
PMID:  9365193     Owner:  NLM     Status:  MEDLINE    
To determine why estriol (E3) levels in the urine and serum are extremely low in pregnancies with anencephalus or hydatidiform mole, both the aromatase activity and the tissue P450arom concentration in solubilized fractions of placental or mole microsomes was measured. The aromatase activity was measured by tritiated water assay and the tissue P450arom concentration was determined by sandwich enzyme-linked immunosorbent assay (ELISA). Consequently, any tissue P450arom concentration was at a lower level than the regression line for that in normal placenta. The aromatase activity also showed a tendency to be lower than that in normal placenta. These results therefore suggest that a decrease of E3 in these abnormal pregnancies would result mainly in a lower level of tissue P450arom concentration.
T Yamamoto; S Inoue; J Kitawaki; H Honjo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of steroid biochemistry and molecular biology     Volume:  61     ISSN:  0960-0760     ISO Abbreviation:  J. Steroid Biochem. Mol. Biol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-12-02     Completed Date:  1997-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9015483     Medline TA:  J Steroid Biochem Mol Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  219-21     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Anencephaly / enzymology*
Aromatase / analysis*,  biosynthesis
Hydatidiform Mole / enzymology*
Placenta / enzymology*
Pregnancy Complications, Neoplastic / enzymology
Uterine Neoplasms / enzymology*
Reg. No./Substance:

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