Document Detail


Quantitative evaluation of Al maltolate-induced neurodegeneration with subsequent Al removal by desferrioxamine treatment.
MedLine Citation:
PMID:  7566688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intracisternal administration of aluminum maltolate to New Zealand white rabbits produces a reproducible neurofibrillary degeneration which is significantly reversed by desferrioxamine treatment. Quantitative analysis of brain and spinal cord tissue demonstrates that the aluminum deposition is higher close to the injection site than at locations further removed from the point of administration. Most importantly, treatment with desferrioxamine removes most of the aluminum from the brain and spinal cord, even from the sites of highest concentration. The ability to manipulate this system in the formation and degradation of NFD and in removal of aluminum may shed light on mechanisms of NFD formation and have implications for therapeutic advances in the treatment of certain human neurodegenerative diseases.
Authors:
Y Huang; J Savory; M M Herman; J R Nicholson; M R Reyes; J C Boyd; M R Wills
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurotoxicology     Volume:  16     ISSN:  0161-813X     ISO Abbreviation:  Neurotoxicology     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-30     Completed Date:  1995-10-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
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MeSH Terms
Descriptor/Qualifier:
Aluminum / metabolism*,  toxicity*
Animals
Chelating Agents / pharmacology*
Deferoxamine / pharmacology*
Male
Nerve Degeneration / drug effects*
Organometallic Compounds / toxicity*
Pyrones / toxicity*
Rabbits
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Organometallic Compounds; 0/Pyrones; 23058-19-7/aluminum maltolate; 70-51-9/Deferoxamine; 7429-90-5/Aluminum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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