| Quantitative electroencephalography for measurement of central nervous system responses to diazepam and the benzodiazepine antagonist, flumazenil, in isoflurane-anaesthetized dogs. | |
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MedLine Citation:
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PMID: 1433489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quantitative EEG was assessed in six dogs anaesthetized with 1.8% end-tidal isoflurane concentration and following diazepam (0.2 mg/kg i.v.) administration. Ventilation was controlled to maintain normocapnia. Five dogs were subsequently given the benzodiazepine antagonist, flumazenil (0.04 mg/kg i.v.), and quantitative EEG was recorded. One dog received a saline injection following diazepam (as a control) and quantitative EEG was recorded for an additional 2.5 h. Heart rate, arterial blood pressure, esophageal temperature, arterial pH and blood gas tensions, end-tidal CO2 tension and end-tidal isoflurane concentration were monitored throughout the study. A 21 lead linked-ear montage was used for recording EEG. Quantitative EEG data were stored on an optical disc for analysis at a later date. Values for absolute power of EEG were determined for theta, delta, alpha, and beta frequencies. Cardiovascular parameters remained stable throughout the study. Diazepam administration was associated with decreased absolute power in all frequencies of EEG at all electrode sites. The duration of diazepam-induced decreased absolute power of EEG was at least 3 h in one dog. Administration of flumazenil antagonized diazepam-induced decreased absolute power of EEG in all frequencies at all electrode sites. We conclude that quantitative EEG provides a relatively non-invasive, objective measure of diazepam- and flumazenil-induced changes in cortical activity during isoflurane anaesthesia. |
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Authors:
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S A Greene; M P Moore; R D Keegan; L V Gallagher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of veterinary pharmacology and therapeutics Volume: 15 ISSN: 0140-7783 ISO Abbreviation: J. Vet. Pharmacol. Ther. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-11-27 Completed Date: 1992-11-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7910920 Medline TA: J Vet Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 259-66 Citation Subset: IM |
Affiliation:
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Department of Veterinary Clinical Medicine and Surgery, Washington State University, Pullman 99164-6610. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Inhalation
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veterinary Animals Brain / drug effects* Diazepam / pharmacology* Dogs / physiology* Electroencephalography / drug effects, veterinary* Female Flumazenil / pharmacology* Hemodynamics / drug effects Isoflurane |
| Chemical | |
Reg. No./Substance:
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26675-46-7/Isoflurane; 439-14-5/Diazepam; 78755-81-4/Flumazenil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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