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Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumors in mice.
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MedLine Citation:
PMID:  4688318     Owner:  NLM     Status:  MEDLINE    
Mice were fed diets deficient in a single essential amino acid, and the primary immune responses to inoculation of allogenic tumor cells was measured by in vitro assay of cellular immunity. Moderate reduction of the amino acids phenylalanine-tyrosine, valine, threonine, methionine-cystine, isoleucine, and tryptophane in the diet produced profound depression of hemagglutinating and blocking antibody responses, although cytotoxic cell-mediated immunity remained intact. These diets had previously been shown to result in a selective depression of tumor growth in mice. Limitation of the amino acids arginine, histidine, and lysine in the diets gave rise to only slight depression of the immune responses. These diets had previously been shown to produce a proportional decrease in both tumor growth and host body weight. Moderate leucine restriction resulted in a paradoxical depression of cytotoxic cell-mediated immunity with little effect on serum blocking activity. Slight increases had previously been noted in the weight of tumors in mice fed leucine-restricted diets. Deficiency or imbalance of essential amino acids in the diet may produce profound depression of immune responses and apparent, marked changes in the immune resistance of the host animal to tumors.
D G Jose; R A Good
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  137     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1973 Jan 
Date Detail:
Created Date:  1973-04-23     Completed Date:  1973-04-23     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  AIM; IM    
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MeSH Terms
Adenocarcinoma / immunology
Amino Acids / administration & dosage,  metabolism*
Antibodies, Neoplasm
Antigen-Antibody Complex
Arginine / administration & dosage
Cells, Cultured
Cysteine / administration & dosage
Cytotoxicity Tests, Immunologic
Deficiency Diseases / immunology*
Histidine / administration & dosage
Immunity, Cellular
Isoleucine / administration & dosage
Lysine / administration & dosage
Mammary Neoplasms, Experimental / immunology*
Methionine / administration & dosage
Mice, Inbred C3H
Mice, Inbred CBA
Phenylalanine / administration & dosage
Threonine / administration & dosage
Time Factors
Tryptophan / administration & dosage
Tyrosine / administration & dosage
Valine / administration & dosage
Reg. No./Substance:
0/Amino Acids; 0/Antibodies, Neoplasm; 0/Antigen-Antibody Complex; 52-90-4/Cysteine; 55520-40-6/Tyrosine; 56-87-1/Lysine; 63-68-3/Methionine; 63-91-2/Phenylalanine; 7004-03-7/Valine; 71-00-1/Histidine; 72-19-5/Threonine; 73-22-3/Tryptophan; 73-32-5/Isoleucine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1973 by The Rockefeller University Press
Received Day: 4 Month: 8 Year: 1972
Print publication date: Day: 1 Month: 1 Year: 1973
Volume: 137 Issue: 1
First Page: 1 Last Page: 9
ID: 2139370
PubMed Id: 4688318

David G. Jose
Robert A. Good
From the Research Laboratories of the Variety Club Heart Hospital, Departments of Pediatrics, Immunobiology, and Pathology, University of Minnesota, Minneapolis, Minnesota 55455

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