| Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumors in mice. | |
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MedLine Citation:
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PMID: 4688318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice were fed diets deficient in a single essential amino acid, and the primary immune responses to inoculation of allogenic tumor cells was measured by in vitro assay of cellular immunity. Moderate reduction of the amino acids phenylalanine-tyrosine, valine, threonine, methionine-cystine, isoleucine, and tryptophane in the diet produced profound depression of hemagglutinating and blocking antibody responses, although cytotoxic cell-mediated immunity remained intact. These diets had previously been shown to result in a selective depression of tumor growth in mice. Limitation of the amino acids arginine, histidine, and lysine in the diets gave rise to only slight depression of the immune responses. These diets had previously been shown to produce a proportional decrease in both tumor growth and host body weight. Moderate leucine restriction resulted in a paradoxical depression of cytotoxic cell-mediated immunity with little effect on serum blocking activity. Slight increases had previously been noted in the weight of tumors in mice fed leucine-restricted diets. Deficiency or imbalance of essential amino acids in the diet may produce profound depression of immune responses and apparent, marked changes in the immune resistance of the host animal to tumors. |
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Authors:
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D G Jose; R A Good |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 137 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1973 Jan |
Date Detail:
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Created Date: 1973-04-23 Completed Date: 1973-04-23 Revised Date: 2010-09-13 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: AIM; IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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immunology Amino Acids / administration & dosage, metabolism* Animals Antibodies, Neoplasm Antigen-Antibody Complex Arginine / administration & dosage Cells, Cultured Cysteine / administration & dosage Cytotoxicity Tests, Immunologic Deficiency Diseases / immunology* Diet Histidine / administration & dosage Immunity, Cellular Isoleucine / administration & dosage Lysine / administration & dosage Male Mammary Neoplasms, Experimental / immunology* Methionine / administration & dosage Mice Mice, Inbred C3H Mice, Inbred CBA Phenylalanine / administration & dosage Threonine / administration & dosage Time Factors Tryptophan / administration & dosage Tyrosine / administration & dosage Valine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Antibodies, Neoplasm; 0/Antigen-Antibody Complex; 52-90-4/Cysteine; 55520-40-6/Tyrosine; 56-87-1/Lysine; 63-68-3/Methionine; 63-91-2/Phenylalanine; 7004-03-7/Valine; 71-00-1/Histidine; 72-19-5/Threonine; 73-22-3/Tryptophan; 73-32-5/Isoleucine; 74-79-3/Arginine |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © 1973 by The Rockefeller University Press Received Day: 4 Month: 8 Year: 1972 Print publication date: Day: 1 Month: 1 Year: 1973 Volume: 137 Issue: 1 First Page: 1 Last Page: 9 ID: 2139370 PubMed Id: 4688318 |
| QUANTITATIVE EFFECTS OF NUTRITIONAL ESSENTIAL AMINO ACID DEFICIENCY UPON IMMUNE RESPONSES TO TUMORS IN MICE | |
| David G. Jose | |
| Robert A. Good | |
| From the Research Laboratories of the Variety Club Heart Hospital, Departments of Pediatrics, Immunobiology, and Pathology, University of Minnesota, Minneapolis, Minnesota 55455 |
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