|Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumors in mice.|
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|PMID: 4688318 Owner: NLM Status: MEDLINE|
|Mice were fed diets deficient in a single essential amino acid, and the primary immune responses to inoculation of allogenic tumor cells was measured by in vitro assay of cellular immunity. Moderate reduction of the amino acids phenylalanine-tyrosine, valine, threonine, methionine-cystine, isoleucine, and tryptophane in the diet produced profound depression of hemagglutinating and blocking antibody responses, although cytotoxic cell-mediated immunity remained intact. These diets had previously been shown to result in a selective depression of tumor growth in mice. Limitation of the amino acids arginine, histidine, and lysine in the diets gave rise to only slight depression of the immune responses. These diets had previously been shown to produce a proportional decrease in both tumor growth and host body weight. Moderate leucine restriction resulted in a paradoxical depression of cytotoxic cell-mediated immunity with little effect on serum blocking activity. Slight increases had previously been noted in the weight of tumors in mice fed leucine-restricted diets. Deficiency or imbalance of essential amino acids in the diet may produce profound depression of immune responses and apparent, marked changes in the immune resistance of the host animal to tumors.|
|D G Jose; R A Good|
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|Type: Journal Article|
|Title: The Journal of experimental medicine Volume: 137 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1973 Jan|
|Created Date: 1973-04-23 Completed Date: 1973-04-23 Revised Date: 2010-09-13|
Medline Journal Info:
|Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: UNITED STATES|
|Languages: eng Pagination: 1-9 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Amino Acids / administration & dosage, metabolism*
Arginine / administration & dosage
Cysteine / administration & dosage
Cytotoxicity Tests, Immunologic
Deficiency Diseases / immunology*
Histidine / administration & dosage
Isoleucine / administration & dosage
Lysine / administration & dosage
Mammary Neoplasms, Experimental / immunology*
Methionine / administration & dosage
Mice, Inbred C3H
Mice, Inbred CBA
Phenylalanine / administration & dosage
Threonine / administration & dosage
Tryptophan / administration & dosage
Tyrosine / administration & dosage
Valine / administration & dosage
|0/Amino Acids; 0/Antibodies, Neoplasm; 0/Antigen-Antibody Complex; 52-90-4/Cysteine; 55520-40-6/Tyrosine; 56-87-1/Lysine; 63-68-3/Methionine; 63-91-2/Phenylalanine; 7004-03-7/Valine; 71-00-1/Histidine; 72-19-5/Threonine; 73-22-3/Tryptophan; 73-32-5/Isoleucine; 74-79-3/Arginine|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Journal ID (nlm-ta): J Exp Med
Publisher: The Rockefeller University Press
Copyright © 1973 by The Rockefeller University Press
Received Day: 4 Month: 8 Year: 1972
Print publication date: Day: 1 Month: 1 Year: 1973
Volume: 137 Issue: 1
First Page: 1 Last Page: 9
PubMed Id: 4688318
|QUANTITATIVE EFFECTS OF NUTRITIONAL ESSENTIAL AMINO ACID DEFICIENCY UPON IMMUNE RESPONSES TO TUMORS IN MICE|
|David G. Jose|
|Robert A. Good|
|From the Research Laboratories of the Variety Club Heart Hospital, Departments of Pediatrics, Immunobiology, and Pathology, University of Minnesota, Minneapolis, Minnesota 55455
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