| Quantitative dynamic contrast-enhanced MRI for mouse models using automatic detection of the arterial input function. | |
| | |
MedLine Citation:
|
PMID: 21954069 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dynamic contrast-enhanced MRI (DCE-MRI) is widely accepted for the evaluation of cancer. DCE-MRI, a noninvasive measurement of microvessel permeability, blood volume and blood flow, is extremely useful for understanding disease mechanisms and monitoring therapeutic responses in preclinical research. For the accurate quantification of pharmacokinetic parameters using DCE-MRI, determination of the arterial input function (AIF) from a large arterial vessel near the tumor is required. However, a manual determination of AIF in mouse MR images is often difficult because of the small spatial dimensions or the location of the tumor. In this study, we propose an algorithm for the automatic detection of AIF from mouse DCE-MR images using Kendall's coefficient of concordance. The proposed method was tested with computer simulations and then applied to tumor-bearing mice (n = 8). Results from computer simulations showed that the proposed algorithm is capable of categorizing simulated AIF signals according to their noise levels. We found that the resulting pharmacokinetic parameters computed from our method were comparable with those from the manual determination of AIF, with acceptable differences in K(trans) (5.14 ± 3.60%), v(e) (6.02 ± 3.22%), v(p) (5.10 ± 7.05%) and k(ep) (5.38 ± 4.72%). The results of the current study suggest the usefulness of an automatically defined AIF using Kendall's coefficient of concordance for quantitative DCE-MRI in mouse models for cancer evaluation. Copyright © 2011 John Wiley & Sons, Ltd. |
| | |
Authors:
|
Jae-Hun Kim; Geun Ho Im; Jehoon Yang; Dongil Choi; Won Jae Lee; Jung Hee Lee |
Related Documents
:
|
18568549 - Prostate cancer detection: comparison of t2-weighted imaging, diffusion-weighted imagin... 22227259 - Detection of metastatic bone lesions in breast cancer patients: fused (18)f-fluoride-pe... 19885309 - Multidisciplinary functional mr imaging for prostate cancer. 17234999 - Functional mr imaging of prostate cancer. 22122739 - Evaluation of diagnostic strategies for bladder cancer using computed tomography (ct) u... 11224749 - Magnetic resonance imaging of the prostate. 14511799 - A mri study of fusiform gyrus in schizotypal personality disorder. 8517289 - Dorsal carpal ligaments of the wrist: normal appearance on multiplanar reconstructions ... 11498419 - Perfusion-sensitive mr imaging of gliomas: comparison between gradient-echo and spin-ec... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-23 |
Journal Detail:
|
Title: NMR in biomedicine Volume: - ISSN: 1099-1492 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Repletion of TNF{alpha} or leptin in calorically restricted mice suppresses post-restriction hyperph...
Next Document: Identification of phenotypes with different clinical outcomes in knee osteoarthritis: Data from the ...