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Quantitative dynamic (18)FDG-PET and tracer kinetic analysis of soft tissue sarcomas.
MedLine Citation:
PMID:  23198721     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose. To study soft tissue sarcomas using dynamic positron emission tomography (PET) with the glucose analog tracer [(18)F]fluoro-2-deoxy-D-glucose ((18)FDG), to investigate correlations between derived PET image parameters and clinical characteristics, and to discuss implications of dynamic PET acquisition (D-PET). Material and methods. D-PET images of 11 patients with soft tissue sarcomas were analyzed voxel-by-voxel using a compartment tracer kinetic model providing estimates of transfer rates between the vascular, non-metabolized, and metabolized compartments. Furthermore, standard uptake values (SUVs) in the early (2 min p.i.; SUV(E)) and late (45 min p.i.; SUV(L)) phases of the PET acquisition were obtained. The derived transfer rates K(1), k(2) and k(3), along with the metabolic rate of (18)FDG (MR(FDG)) and the vascular fraction ν(p), was fused with the computed tomography (CT) images for visual interpretation. Correlations between D-PET imaging parameters and clinical parameters, i.e. tumor size, grade and clinical status, were calculated with a significance level of 0.05. Results. The temporal uptake pattern of (18)FDG in the tumor varied considerably from patient to patient. SUV(E) peak was higher than SUV(L) peak for four patients. The images of the rate constants showed a systematic pattern, often with elevated intensity in the tumors compared to surrounding tissue. Significant correlations were found between SUV(E/L) and some of the rate parameters. Conclusions. Dynamic (18)FDG-PET may provide additional valuable information on soft tissue sarcomas not obtainable from conventional (18)FDG-PET. The prognostic role of dynamic imaging should be investigated.
Authors:
Espen Rusten; Jan Rødal; Mona E Revheim; Arne Skretting; Oyvind S Bruland; Eirik Malinen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  -     ISSN:  1651-226X     ISO Abbreviation:  Acta Oncol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medical Physics, The Norwegian Radium Hospital, Oslo University Hospital , Oslo , Norway.
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