| Quantitative diffusion imaging in breast cancer: a clinical prospective study. | |
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MedLine Citation:
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PMID: 16786565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study the correlation between apparent diffusion coefficient (ADC) and pathology in patients with undefined breast lesion, to validate how accurately ADC is related to histology, and to define a threshold value of ADC to distinguish malignant from benign lesions. MATERIALS AND METHODS: Seventy-eight patients (110 lesions) were referred for positive or dubious findings. Three-dimensional fast low-angle shot (3D-FLASH) with contrast injection was applied. EPI diffusion-weighted imaging (DWI) with fat saturation was performed, and ROIs were selected on subtraction 3D-FLASH images before and after contrast injection, and copied on an ADC map. Inter- and intraobserver analyses were performed. RESULTS: At pathology 22 lesions were benign, 65 were malignant, and 23 were excluded. The ADCs of malignant and benign lesions were statistically different. In malignant tumors the ADC was (mean +/- SEM) 0.95 +/- 0.027 x 10(-3)mm(2)/second, and in benign tumors it was 1.51 +/- 0.068 x 10(-3)mm(2)/second. According to receiver operating characteristic (ROC) curves, we found a threshold between malignant and benign lesions for highest sensitivity and specificity (both 86%) around 1.13 +/- 0.10 x 10(-3)mm(2)/second. For a threshold of 0.95 +/- 0.10 x 10(-3)mm(2)/second, specificity was 100% but sensitivity was very low. Inter- and intraobserver studies showed good reproducibility. CONCLUSION: The ADC may help to differentiate benign and malignant lesions with good specificity, and may increase the overall specificity of breast MRI. |
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Authors:
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Erika Rubesova; Anne-Sophie Grell; Viviane De Maertelaer; Thierry Metens; Shih-Li Chao; Marc Lemort |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 24 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-24 Completed Date: 2006-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: IM |
Affiliation:
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Department of Radiology, CHU Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium. erubesova@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast Neoplasms / pathology* Contrast Media / administration & dosage Diagnosis, Differential Diffusion Magnetic Resonance Imaging* Female Gadolinium DTPA / administration & dosage Humans Image Processing, Computer-Assisted Middle Aged Prospective Studies ROC Curve Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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