Document Detail


Quantitative deoxyribonucleic acid analysis of patients with mild cervical atypia: a potentially malignant lesion?
MedLine Citation:
PMID:  3037459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quantitative deoxyribonucleic acid (DNA) analysis of cervical biopsy material from 32 women with cytologic, colposcopic, and histologic evidence of mild cervical atypia consistent with cervical intraepithelial neoplasia I, reactive atypia, or human papillomavirus infection was carried out using flow cytometry and Feulgen microspectrophotometry. Evidence of aneuploidy, ie, neoplastic transformation, was demonstrated in all cases of cervical intraepithelial neoplasia I and 68% of cases with human papillomavirus-induced atypia. These results support the growing impression that human papillomavirus-induced cervical atypia should be regarded as a true precursor of cervical neoplasia, and emphasize the necessity to refer patients with mild atypia for definitive diagnosis and management.
Authors:
K C Watts; M J Campion; E B Butler; D Jenkins; A Singer; O A Husain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  70     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-08-19     Completed Date:  1987-08-19     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Carcinoma in Situ / genetics,  pathology*
DNA, Neoplasm / analysis*
Female
Flow Cytometry
Humans
Papillomaviridae
Precancerous Conditions / genetics,  pathology*
Spectrophotometry
Tumor Virus Infections / genetics,  pathology
Uterine Cervical Neoplasms / genetics,  pathology*
Chemical
Reg. No./Substance:
0/DNA, Neoplasm

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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