| Quantitative cytology in ovarian carcinoma ascitic fluids. | |
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MedLine Citation:
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PMID: 10800615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the value of quantitative methods in the differential diagnosis between ovarian carcinoma cells and mesothelial cells in ascitic fluids. STUDY DESIGN: Ninety ascitic fluid samples, previously reported as positive for ovarian carcinoma (30 cases), suspicious for malignancy (30) and negative for malignancy, containing only reactive mesothelial cells (30), were retrieved from the files. In each of these specimens the nuclear area, perimeter, roundness and shape coefficient of 100 cells were determined at 630 x magnification. Statistical analysis was performed using analysis of variance and, for multiple comparisons, the Student-Newman-Keuls technique. RESULTS: Mean values for nuclear area and perimeter were higher in malignant cells as compared to reactive mesothelial cells, whereas those for roundness and shape coefficients were lower. All differences were statistically significant, the former two at a .05 level and the latter at the .001 level. CONCLUSION: Quantitative methods can reliably support the differential diagnosis between ovarian carcinoma cells and mesothelial cells in ascitic fluid specimens. |
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Authors:
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A Kalogeraki; J Panayiotides; M Tzardi; D Tamiolakis; G Datseris; J Vlachonikolis; G S Delides |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology Volume: 22 ISSN: 0884-6812 ISO Abbreviation: Anal. Quant. Cytol. Histol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-30 Completed Date: 2000-06-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8506819 Medline TA: Anal Quant Cytol Histol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 139-42 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Crete Medical School, Herakleion, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Ascitic Fluid / cytology, pathology* Cell Nucleus / pathology Cell Size Diagnosis, Differential Epithelial Cells / cytology* Female Humans Image Cytometry / methods* Middle Aged Ovarian Neoplasms / diagnosis*, pathology* Predictive Value of Tests |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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