| Quantitative comparison of magnetic resonance imaging (MRI) and histologic analyses of focal ischemic damage in the rat. | |
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MedLine Citation:
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PMID: 2012989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemispheric swelling and area of infarction, two parameters of cerebral focal ischemic damage, were identified and quantified from T2-weighted magnetic resonance imaging (MRI) two days after occlusion of the middle cerebral artery (MCAO) in spontaneously hypertensive rat (SHR) brains. Results were compared with these measures quantified from 2,3,5-triphenyltetrazolium hydrochloride (TTC)- and hematoxylin and eosin (H&E)-stained histologic sections in the same brains. The degree of hemispheric swelling and infarct size determined by MRI were highly correlated to the measurements as determined in the TTC- and H&E-stained tissues. These results demonstrate that the focal ischemic damaged area and associated tissue swelling identified by MRI is quantitatively similar to, and thus, is representative of actual tissue damage/changes that can be identified by gross or histologic examination. |
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Authors:
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F C Barone; R K Clark; G Feuerstein; R E Lenkinski; S K Sarkar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research bulletin Volume: 26 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-05-16 Completed Date: 1991-05-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 285-91 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, SmithKline Beecham Pharmaceuticals, plc, King of Prussia, PA 19406. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebral Infarction / diagnosis Ischemic Attack, Transient / diagnosis* Magnetic Resonance Imaging* Rats Rats, Inbred SHR |
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