| Quantitative chemical shift imaging of vertebral bone marrow in patients with Gaucher disease. | |
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MedLine Citation:
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PMID: 1732964 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate extent of bone marrow involvement and disease severity in Gaucher patients, results of modified Dixon quantitative chemical shift imaging (QCSI) of the lumbar spine were correlated with quantitative analysis of marrow triglycerides and glucocerebrosides and with quantitative determination of splenic volume at magnetic resonance (MR) imaging. High-field-strength MR spectra of surgical marrow specimens were dominated by a single fat and a water peak, validating use of QCSI. QCSI showed average vertebral marrow fat fractions of 10% +/- 8 in Gaucher patients (normal adult averages, 29% +/- 6). Relaxation times for lipid and water approximated normal averages; bulk T1 values were significantly longer, reflecting decreased marrow fat. Glucocerebroside concentrations were higher in Gaucher marrow and inversely correlated with triglyceride concentrations. Extent of marrow infiltration determined by fat fraction measurements correlated with disease severity measured by splenic enlargement. These results show that as Gaucher cells infiltrate bone marrow and displace normal marrow adipocytes, bulk T1 increases due to the higher T1 of water compared with that of fat. QCSI provides a sensitive, noninvasive technique for evaluating bone marrow involvement in Gaucher disease. |
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Authors:
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L A Johnson; B E Hoppel; E L Gerard; S P Miller; S H Doppelt; G C Zirzow; D I Rosenthal; J M Dambrosia; S C Hill; R O Brady |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Radiology Volume: 182 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-02-25 Completed Date: 1992-02-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 451-5 Citation Subset: AIM; IM |
Affiliation:
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MGH-NMR Center, Department of Radiology, Massachusetts General Hospital, Charlestown 02129. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Water
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metabolism Bone Marrow / chemistry* Gaucher Disease / metabolism*, pathology Glucosylceramides / analysis Humans Lipids / analysis Lumbar Vertebrae* Magnetic Resonance Spectroscopy* Spleen / pathology Triglycerides / analysis |
| Grant Support | |
ID/Acronym/Agency:
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R01-CA-40303/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucosylceramides; 0/Lipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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