| Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 tesla MRI. | |
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MedLine Citation:
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PMID: 21987483 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To develop imaging techniques that provide quantitative characterization of bone marrow edema pattern (BME) in wrist joints of patients with rheumatoid arthritis (RA), including volume, signal intensity changes, and perfusion properties. MATERIALS AND METHODS: Fourteen RA patients and three controls were scanned using 3 Tesla MR. BME was semi-automatically segmented in water images obtained from iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) sequences. BME perfusion parameters (enhancement and slope) were evaluated using three-dimensional (3D) dynamic enhanced MRI (DCE-MRI). Experimental reproducibility, inter- and intra-observer reproducibility of BME quantification were evaluated using root mean square coefficients of variation (RMS-CV) and intraclass correlation (ICC). RESULTS: The RMS-CV for BME volume quantification with repeated scans were 6.9%. The inter-observer ICC was 0.993 and RMS CV was 5.2%. The intra-observer ICC was 0.998 and RMS CV was 2.3%. Both maximum enhancement and slope during DCE-MRI were significantly higher in BME than in normal bone marrow (P < 0.001). No significant correlation was found between BME quantification and clinical evaluations. CONCLUSION: A highly reproducible semi-automatic method for quantifying BME lesion burden in RA was developed, which may enhance our capability of predicting disease progression and monitoring treatment response. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. |
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Authors:
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Xiaojuan Li; Andrew Yu; Warapat Virayavanich; Susan M Noworolski; Thomas M Link; John Imboden |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-10 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, California, USA. xiaojuan.li@ucsf.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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