Document Detail

Quantitative changes in the cellular population of the growth plate of triamcinolone-treated mice.
MedLine Citation:
PMID:  883485     Owner:  NLM     Status:  MEDLINE    
Triamcinolone-induced changes in the number of cartilage within the proximal growth plate of the humerus were determined in ICR male mice. It was found that pharmacological doses of corticosteroid hormone possess a direct inhibitory effect upon the proliferative activity of young cartilage cells and thereby adversely affect the growth potential of this growth center. Concomitantly, the activity of chondroclasts also appears to be depressed, thus resulting in a decreased rate of cartilage reorption followed by a slight increase in the number of hypertrophic chondrocytes. It therefore appears that systemic treatment with corticosteroid hormones inhibits the renewal of cartilage cells in the epiphyseal plate, leading to an accelerated 'aging' of this growth center with subsequent impairment of long bone growth.
M Silbermann; T Kadar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anatomica     Volume:  98     ISSN:  0001-5180     ISO Abbreviation:  Acta Anat (Basel)     Publication Date:  1977  
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  0370272     Medline TA:  Acta Anat (Basel)     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  396-400     Citation Subset:  IM    
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MeSH Terms
Bone Development / drug effects*
Cartilage / drug effects
Cell Division / drug effects
Epiphyses / drug effects,  growth & development*
Humerus / growth & development
Mice, Inbred ICR
Triamcinolone / pharmacology*
Reg. No./Substance:

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