Document Detail


Quantitative cell fusion: derivation and application of theoretical models.
MedLine Citation:
PMID:  7221837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell fusion experiments were made on ten cell lines representing seven mammalian species, using inactivated Sendai virus. The extent of fusion was determined microscopically and tabulated as frequencies of cell with different numbers of nuclei. Expected distributions were derived theoretically under certain assumptions concerning the fusion process. A random model was assumed according to which the tendency to fuse depends only on the cell size, expressed as the number of nuclei present in the cell. Three distributions were derived, which were referred to as the simple, additive, and multiplicative models. The additive model pertained to fusions made in cell suspensions and the multiplicative one mainly to fusions in fibroblast monolayers.
Authors:
D Röhme; D Thorburn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Somatic cell genetics     Volume:  7     ISSN:  0098-0366     ISO Abbreviation:  Somatic Cell Genet.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506054     Medline TA:  Somatic Cell Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-57     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Fusion*
Cell Line
Mathematics
Models, Biological*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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