| Quantitative bronchoscopic assessment of airway collapsibility in newborn lamb tracheae. | |
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MedLine Citation:
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PMID: 9621995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To date, quantitative studies of the inherent characteristics of the developing airway wall have required excision of an airway segment or surgical creation of an isolated segment. We hypothesized that airway wall characteristics, at various collapsing pressures, and attendant changes in stiffness after smooth muscle stimulation could be quantitated bronchoscopically from airway pressure-area relationships. Neonatal lamb tracheal segments (n = 12) were suspended over hollow mounts, in a buffer-filled chamber, and subjected to a range (0 to -4.0 kPa) of pressures to determine wall stiffness under collapsing forces before and after stimulation of the trachealis with methacholine. Luminal images were recorded through a 3.6-mm flexible bronchoscope under the same conditions, subsequently corrected for distortion, and a cross-sectional area was quantitated. Both pressure-volume and pressure-area relationships detected significant changes in airway wall stiffness after methacholine administration (p < 0.002), and the magnitude of change was similar between methods. These data suggest that quantitative flexible bronchoscopy can be used clinically in the intact airway to assess wall stiffness. |
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Authors:
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H B Panitch; I Talmaciu; J Heckman; M R Wolfson; T H Shaffer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 43 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-08-07 Completed Date: 1998-08-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 832-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Allegheny University of the Health Sciences, MCP-Hahnemann School of Medicine, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania 19134-1095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Bronchoconstrictor Agents / pharmacology Bronchoscopes Bronchoscopy / methods* Methacholine Chloride / pharmacology Pressure Sheep Trachea / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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