| Quantitative brain FDG/PET studies using dynamic aortic imaging. | |
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MedLine Citation:
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PMID: 15552117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron emission tomography (PET) measurements of cerebral glucose utilization using 18F-fluorodeoxyglucose (FDG) are a useful tool in the investigation of localized brain function in normal and disease states. A major impediment to the application of FDG/PET in clinical investigation has been the need for arterial blood sampling to quantify cerebral glucose metabolism (CMRGlc). Qualitative studies, though informative in a variety of clinical settings, are of limited value for research applications and do not utilize the inherent quantitative nature of PET. We present a novel PET technique employing a whole-body PET tomograph with abdominal aortic imaging from 0 to 30 min as an alternative to arterial blood sampling to obtain the input function for cerebral metabolic rate calculations. Two or three arterial samples taken during the 10-45 min period were used to scale and extend the blood curve and the brain was imaged from 35-55 min post-injection. We performed 12 studies in which both arterial blood sampling and aortic scans were obtained. We found the correlation of global metabolic rates (GMR) when comparing the two techniques to be extremely high (R2 = 0.99). This suggests that the use of dynamic aortic imaging is less invasive and a viable alternative to arterial blood sampling in quantitative FDG/PET imaging. |
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Authors:
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V Dhawan; S Takikawa; W Robeson; P Spetsieris; T Chaly; R Dahl; I Zanzi; D Bandyopadhyay; D Margouleff; D Eidelberg |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Physics in medicine and biology Volume: 39 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 1994 Sep |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2004-12-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1475-87 Citation Subset: IM |
Affiliation:
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Department of Neurology, North Shore University Hospital--Cornell University Medical College, Manhasset, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Aorta, Abdominal / metabolism, radionuclide imaging* Brain / blood supply*, metabolism, radionuclide imaging* Female Fluorodeoxyglucose F18 / blood, diagnostic use*, pharmacokinetics Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Positron-Emission Tomography / methods* Radiopharmaceuticals / blood, diagnostic use, pharmacokinetics Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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