Document Detail


Quantitative brain diffusion-tensor MRI findings in patients with sickle cell disease.
MedLine Citation:
PMID:  22528909     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to evaluate the microstructure of various regions of the brain using diffusion-tensor imaging (DTI) in patients with sickle cell disease (SCD) and in age- and sex-matched healthy control subjects. We also investigated the fiber tractography findings of the corpus callosum (CC) and corticospinal tracts (CSTs).
SUBJECTS AND METHODS: Sixteen right-handed patients with SCD and 14 age- and sex-matched right-handed healthy control subjects were scanned using conventional MR sequences and DTI. Fractional anisotropy (FA) and apparent diffusion coefficients (ADCs) were calculated and regions of interest were selected in various brain areas (superior and inferior frontal, parietal, occipital, and temporal white matter areas), anterior and posterior periventricular areas, centrum semiovale, basal ganglia (lentiform nucleus, head of caudate nucleus), thalamus, cerebral peduncles, pons, cerebellar white matter areas, and CC. Diffusion-tensor tractography of the CC and CSTs was also performed.
RESULTS: For the patients with SCD, significantly reduced FA values, increased ADC values, or both were seen clustered in several brain areas, including the CC, frontal white matter, centrum semiovale, periventricular areas, head of the caudate nucleus, thalamus, brainstem, and pons (p < 0.05). Statistically significant reductions in fiber counts in the first and fifth segments of the CC and in CSTs bilaterally were also observed in patients with SCD (p < 0.05).
CONCLUSION: DTI shows microstructural abnormalities of various brain areas in patients with SCD.
Authors:
Ali Balci; Sinem Karazincir; Yeliz Beyoglu; Cihangir Cingiz; Ramazan Davran; Edip Gali; Esra Okuyucu; Ertugrul Egilmez
Related Documents :
22388349 - Inhibition of drp1 provides neuroprotection in vitro and in vivo.
22455839 - Bilateral subcortical heterotopia with partial callosal agenesis in a mouse mutant.
22536169 - Digital reconstructions of neuronal morphology: three decades of research trends.
22540729 - Modulating the precision of recurrent bursts in cultured neural networks.
22514289 - A neuronal population in hypothalamus that dramatically resists acute ischemic injury c...
22520189 - The emergence of nervennahrung: nerves, mind and metabolism in the long eighteenth cent...
8761929 - Differential glutamatergic innervation in cytochrome oxidase-rich and -poor regions of ...
7775329 - Activity of respiratory neurons during hypoxia in the chemodenervated cat.
20181579 - The progenitor zone of the ventral medial ganglionic eminence requires nkx2-1 to genera...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  198     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1167-74     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Mustafa Kemal University, Faculty of Medicine, Serinyol Kampüsü, Antakya, Hatay 31100, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  New criteria for the sonographic diagnosis of a plaque ulcer in the extracranial carotid artery.
Next Document:  Utility of FDG PET/CT in the assessment of myeloid sarcoma.