Document Detail

Quantitative brain MR imaging in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  21404113     Owner:  NLM     Status:  MEDLINE    
OBJECT: To evaluate the potential of quantitative MR techniques [voxel-based morphometry (VBM), T2-relaxometry, mean diffusivity (MD), fractional anisotropy (FA)] in the diagnostics of amyotrophic lateral sclerosis (ALS).
MATERIALS AND METHODS: Thirty-three ALS patients and thirty age- and sex-matched healthy volunteers were included in the cross-sectional study. T1WI, T2WI and T2 relaxometry sequences were performed at 1.5T. DWI was performed in a subgroup of 12 patients. Disease severity was estimated with the ALS Functional Rating Scale (ALS-FRS).
RESULTS: We detected decreased T2 relaxation rate (R2) in the frontal white matter (FWM) (left and right P < 0.005) and caudate nucleus (left P < 0.005) in ALS patients. R2 in the FWM correlated with age in patients and controls. A correlation (P < 0.01, cluster-level corrected) between atrophy in the corona radiata and the limb ALS-FRS subset was found, as well as a difference between patients and controls in this area. No correlation between FA/MD and ALS-FRS was observed in the T2 hyperintense region of the posterior limb of the internal capsule (PLIC), or in the site of atrophy detected by VBM. No R2 or PD changes in the PLIC were detected. TBSS revealed decreased FA in the corona radiata and callosal body.
CONCLUSIONS: Decreased R2 in the left caudate and bilateral FWM may help in the diagnostic process and disqualifies these regions as internal controls in ALS studies. The PLIC is not a reliable diagnostic marker of ALS.
Jiří Keller; Josef Vymazal; Petr Ridzoň; Robert Rusina; Petr Kulišt'ák; Hana Malíková; Aaron M Rulseh; Otakar Keller; Robert Jech
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-15
Journal Detail:
Title:  Magma (New York, N.Y.)     Volume:  24     ISSN:  1352-8661     ISO Abbreviation:  MAGMA     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-24     Completed Date:  2011-06-13     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  9310752     Medline TA:  MAGMA     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  67-76     Citation Subset:  IM    
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MeSH Terms
Amyotrophic Lateral Sclerosis / diagnosis*
Brain / pathology*
Cross-Sectional Studies
Diffusion Magnetic Resonance Imaging / methods*
Middle Aged
Severity of Illness Index

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