| Quantitative autoradiography of parathyroid glands in rats with carbon-14-labeled amino acids. | |
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MedLine Citation:
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PMID: 3498018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have utilized a quantitative autoradiographic method as a means of evaluating amino acid uptake of the rat parathyroid gland for the ultimate purpose of finding agents potentially suitable for position emission tomographic scanning of parathyroid glands. L-[1-14C]leucine and L-[guanido-14C]arginine were evaluated because of their relatively high content in the synthetic products of the parathyroid glands compared with other neck tissues, thyroid gland, and muscle. Carbon-14 leucine disappeared rapidly from plasma following intravenous injection and there was relatively selective uptake of the [14C]leucine and [14C]arginine by the parathyroid glands when compared with uptake by the thyroid gland and neck muscle. These data suggest that both agents warrant further investigation for their potential utility in positron emission tomographic scanning of the parathyroid gland. |
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Authors:
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J A Wortman; A Alavi; M Attie; A P Yudd; S A Johnston; J Greenberg |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 28 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1987-10-14 Completed Date: 1987-10-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1447-52 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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diagnostic use*,
metabolism Animals Arginine / diagnostic use, metabolism Autoradiography Carbon Radioisotopes / diagnostic use* Leucine / diagnostic use, metabolism Male Parathyroid Glands / metabolism, radionuclide imaging* Rats Tomography, Emission-Computed* |
| Grant Support | |
ID/Acronym/Agency:
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GM-07900-04/GM/NIGMS NIH HHS; S07-RR-05415/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Carbon Radioisotopes; 61-90-5/Leucine; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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