Document Detail

Quantitative assessment of the total myocardial uptake ratio of 123I-BMIPP by using the Ishii-MacIntyre method is useful for predicting cardiac complications in patients with mitochondrial encephalomyopathy or myotonic dystrophy.
MedLine Citation:
PMID:  12548043     Owner:  NLM     Status:  MEDLINE    
We evaluated the usefulness of the total myocardial uptake ratio (TMUR) of 15-(p-[123I]iodophenyl)-3(R,S)-methyl-pentadecanoic acid (123I-BMIPP) for predicting cardiac complications in patients with mitochondrial encephalomyopathy or myotonic dystrophy. Six patients with mitochondrial encephalomyopathy, four with myotonic dystrophy, and 10 control subjects were studied. Quantitative assessment of 123I-BMIPP dynamic myocardial imaging was performed, and the TMUR of 123I-BMIPP was calculated according to the Ishii-MacIntyre method. Then, the TMUR was compared in the 10 patients and 10 healthy controls, and all patients were followed for 56.1+/-22.1 months to evaluate cardiac complications. TMUR in patients (2.69+/-0.64) was significantly (P =0.01) lower than that in controls (3.28+/-0.25). Three patients in whom the TMUR value was above 3.00 had no cardiac complications. On the other hand, all patients in whom TMUR was below 3.00 had some kind of cardiac complication during the follow-up period. Two patients showed progressive conduction abnormality and underwent pacemaker implantation, one patient had sick sinus syndrome and underwent pacemaker implantation, another patient showed non-sustained ventricular tachycardia and paroxysmal atrial fibrillation, and four of seven patients, including one with a pacemaker, showed an increased cardiothoracic ratio value over 50%. In conclusion, measurement of the TMUR by the Ishii-MacIntyre method is useful for evaluating the development of cardiac complications in patients with mitochondrial encephalomyopathy or myotonic dystrophy.
Y Ohkusu; N Takahashi; T Ishikawa; S Sumita; T Kobayashi; K Matsushita; Y Yamakawa; K Uchino; K Kimura; T Inoue; S Umemura
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Validation Studies    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  24     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-27     Completed Date:  2003-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  183-90     Citation Subset:  IM    
Second Department of Internal Medicine, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
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MeSH Terms
Fatty Acids / diagnostic use*,  pharmacokinetics
Heart / radionuclide imaging
Heart Diseases / diagnosis,  etiology,  radionuclide imaging*
Iodobenzenes / diagnostic use*,  pharmacokinetics
Longitudinal Studies
Mitochondrial Encephalomyopathies / complications,  metabolism,  radionuclide imaging*
Myocardium / metabolism
Myotonic Dystrophy / complications,  metabolism,  radionuclide imaging*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Reference Values
Reproducibility of Results
Retrospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Fatty Acids; 0/Iodobenzenes; 0/Radiopharmaceuticals; 116754-87-1/iodofiltic acid

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