Document Detail

Quantitative assessment of therapeutic effects in the critically ischemic limb using (99m)Tc-diethylene-triamine-pentaacetic acid human serum albumin.
MedLine Citation:
PMID:  19132462     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the reliability and limitations of a new radioisotope method using (99m)Tc-diethylenetriamine-pentaacetic acid human serum albumin (Tc-99m-DTPA-HSA) and to evaluate the diagnostic ability of isotope infusion for assessing hemodynamic changes in the foot before and after treatment. METHODS: Hemodynamic changes before and after treatment were assessed in 21 limbs with ulcer or gangrene, by analyzing changes in the time-activity curve, the uptake ratio, and the values obtained with noninvasive techniques. RESULTS: There were significant differences between each pair of the three types of time-activity curve and their uptake counts. The uptake ratio was correlated with ankle blood pressure (ABP) and toe blood pressure (TBP), but not with transcutaneous oxygen pressure (tcPO(2)) or skin perfusion pressure (SPP). The hemodynamic change induced by pharmacotherapy was subtle, but that induced by arterial reconstruction was remarkable. Although there was not always a good correlation between the degree of hemodynamic change and the clinical outcome in limbs treated with pharmacotherapy, the hemodynamic change was quantitatively assessed. CONCLUSION: Our study suggests that this isotope technique is a useful quantitative method to evaluate hemodynamic change from a different perspective to conventional noninvasive methods.
Jun Kawanishi; Takashi Ohta; Hiroyuki Ishibashi; Ikuo Sugimoto; Hirohide Iwata; Masayuki Takahashi; Tetsuya Yamada; Noriyuki Hida
Publication Detail:
Type:  Journal Article     Date:  2009-01-08
Journal Detail:
Title:  Surgery today     Volume:  39     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  14-20     Citation Subset:  IM    
Department of Vascular Surgery, Aichi Medical University, 21 Karimata, Yazako, Nagakute-cho, Aichi, 480-1195, Japan.
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MeSH Terms
Arteriosclerosis Obliterans / complications,  surgery
Blood Gas Monitoring, Transcutaneous
Blood Pressure
Evaluation Studies as Topic
Foot / blood supply*
Ischemia* / diagnosis,  physiopathology,  radionuclide imaging,  therapy
Perfusion Imaging / methods
Risk Factors
Technetium Tc 99m Aggregated Albumin / diagnostic use*
Technetium Tc 99m Pentetate / diagnostic use*
Thromboangiitis Obliterans / complications,  surgery
Treatment Outcome
Reg. No./Substance:
0/Technetium Tc 99m Aggregated Albumin; 0/technetium Tc 99m DTPA HSA; 65454-61-7/Technetium Tc 99m Pentetate

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