| Quantitative assessment of strain and strain rate by velocity vector imaging during dobutamine stress echocardiography to predict outcome in patients with left bundle branch block. | |
| | |
MedLine Citation:
|
PMID: 19766454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Abnormal septal motion in left bundle branch block (LBBB) may compromise the interpretation of regional wall motion. Velocity vector imaging (VVI) has been proposed as an objective method to quantify regional myocardial deformation. The aim of this study was to determine whether VVI during dobutamine stress echocardiography (DSE) has prognostic value in patients with LBBB. METHODS: In 84 patients with (mean age, 75 +/- 9 years) undergoing DSE, longitudinal peak systolic strain (epsilon(sys)) and strain rate (SR(sys)) were measured in 16 segments using VVI. Results were expressed as average SR(sys) and epsilon(sys) per patient. Follow-up was obtained for the combined endpoint of mortality, myocardial infarction, and coronary revascularization. Contributions of clinical, conventional dobutamine stress echocardiographic, and epsilon(sys) and SR(sys) variables to outcome were assessed using Cox models. RESULTS: During a mean follow-up period of 18.3 +/- 13.8 months, 23 patients had endpoints. Wall motion score index at rest was the only independent predictor in a model combining clinical and conventional dobutamine stress echocardiographic variables. However, when epsilon(sys) and SR(sys) variables were considered, average SR(sys) at peak stress (hazard ratio, 2.38 per 0.2/s increment; 95% confidence interval, 1.53-3.88; P < .0001) became the only independent predictor of outcome. Using average SR(sys) at peak of -0.5/s as the cut point maximized the model chi(2) value for the prediction of outcomes (model chi(2) = 18.71, P = .002). The annualized event-free survival in patients with average SR(sys) at peak stress lower and higher than -0.5/s were 89.9% and 45.9%, respectively (P < .0001). CONCLUSION: Average SR(sys) at peak stress during DSE offers prognostic information incremental to wall motion analysis in patients with LBBB. |
| | |
Authors:
|
Ying Shan; Hector R Villarraga; Cristina Pislaru; Aijaz A Shah; Stephen S Cha; Patricia A Pellikka |
Related Documents
:
|
10666354 - Safety and prognostic value of early dobutamine-atropine stress echocardiography in pat... 4025154 - Comparative vasoactive therapy for heart failure. 10704164 - Fast determination of regional myocardial strain fields from tagged cardiac images usin... 623004 - Thallium-20 1 myocardial perfusion scintigraphy for the clinical clarification of norma... 6333914 - Myocardial metabolism and haemodynamic responses with enflurane anaesthesia for coronar... 7019244 - Early recovery of regional performance in salvaged ischemic myocardium following corona... |
Publication Detail:
|
Type: Journal Article Date: 2009-09-18 |
Journal Detail:
|
Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 22 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-11-03 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
|
Languages: eng Pagination: 1212-9 Citation Subset: IM |
Affiliation:
|
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Bundle-Branch Block / mortality, physiopathology, ultrasonography* Chi-Square Distribution Echocardiography, Stress* Female Humans Male Prognosis Proportional Hazards Models Reproducibility of Results Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors affecting sensitivity and specificity of diagnostic testing: dobutamine stress echocardiogra...
Next Document: A multilevel item response theory model was investigated for longitudinal vision-related quality-of-...