Document Detail

Quantitative assessment of spray vs immersion fixation for thyroid fine-needle aspiration specimens.
MedLine Citation:
PMID:  20395528     Owner:  NLM     Status:  MEDLINE    
Whether spray or immersion fixation results in higher adequacy rates for thyroid fine-needle aspiration is not known. I compared 1-year adequacy rates, number of cells, and atypia rates for immersion fixation with split spray fixation and immersion. Adequacy rates increased from 71.9% (289/402) for complete immersion to 78.1% (332/425) with spray fixation of half of the slides (P = .02). The spray-fixed slides had an average + or - SD of 49.7 + or - 47.5 cells compared with their paired immersed slides, with 25.4 + or - 36.8 cells (96% more cells for spray fix; P < .001). Of the 402 immersion cases, 10 (2.5%) were diagnosed as atypical related to preparation artifact compared with 14 (3.3%) of cases with split preparation (P = .48). Spray fixation results in 96% more follicular cells in scant thyroid aspirates than immersion fixation and a significant increase in adequate aspirates without a significant increase in the atypia rate related to preparation.
Andrew A Renshaw
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  133     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  796-8     Citation Subset:  AIM; IM    
Department of Pathology, Baptist Hospital, 8900 N Kendall Dr, Miami, FL 33176, USA.
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MeSH Terms
Biopsy, Fine-Needle / methods*
Cell Count
Thyroid Diseases / diagnosis*
Thyroid Gland / pathology*
Tissue Fixation / methods*
Reg. No./Substance:

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