| Quantitative assessment of spray vs immersion fixation for thyroid fine-needle aspiration specimens. | |
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MedLine Citation:
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PMID: 20395528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether spray or immersion fixation results in higher adequacy rates for thyroid fine-needle aspiration is not known. I compared 1-year adequacy rates, number of cells, and atypia rates for immersion fixation with split spray fixation and immersion. Adequacy rates increased from 71.9% (289/402) for complete immersion to 78.1% (332/425) with spray fixation of half of the slides (P = .02). The spray-fixed slides had an average + or - SD of 49.7 + or - 47.5 cells compared with their paired immersed slides, with 25.4 + or - 36.8 cells (96% more cells for spray fix; P < .001). Of the 402 immersion cases, 10 (2.5%) were diagnosed as atypical related to preparation artifact compared with 14 (3.3%) of cases with split preparation (P = .48). Spray fixation results in 96% more follicular cells in scant thyroid aspirates than immersion fixation and a significant increase in adequate aspirates without a significant increase in the atypia rate related to preparation. |
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Authors:
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Andrew A Renshaw |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 133 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 796-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Baptist Hospital, 8900 N Kendall Dr, Miami, FL 33176, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy, Fine-Needle
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methods* Cell Count Fixatives Humans Thyroid Diseases / diagnosis* Thyroid Gland / pathology* Tissue Fixation / methods* |
| Chemical | |
Reg. No./Substance:
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0/Fixatives |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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