Document Detail

Quantitative assessment of the ontogeny of met-enkephalin, norepinephrine and epinephrine in the human fetal adrenal medulla.
MedLine Citation:
PMID:  3394476     Owner:  NLM     Status:  MEDLINE    
The catecholamine producing cells of the adrenal medulla of fetal as well as adult mammals contain enkephalins. We have quantified met-enkephalin and the catecholamines, norepinephrine and epinephrine, in human fetal adrenal glands during the late first trimester and throughout the second trimester of intrauterine life. Met-enkephalin (ME) was detectable in human fetal adrenals of 11 to 25 weeks' gestation by RIA. ME concentrations were low through 14 weeks (mean 279 +/- 199 pg/gland), higher but extremely variable from 15 to 20 weeks (mean 1100 +/- 1000 pg/gland), and then lower with somewhat less variation through 25 weeks (mean 865 +/- 625 pg/gland). In contrast, catecholamine concentrations were below 1100 ng/gland through 16 weeks, then increased markedly by 21 weeks. Approximately equal concentrations of norepinephrine and epinephrine were measured throughout the gestational age period studied. Our data demonstrate that enkephalin is present in the human fetal adrenal at least by 11 weeks' gestation and suggest that the fetal adrenal may be capable of secreting enkephalins as well as catecholamines. The functional significance of adrenal enkephalin secretion remains to be elucidated.
L A Wilburn; R B Jaffe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta endocrinologica     Volume:  118     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-17     Completed Date:  1988-08-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  453-9     Citation Subset:  IM    
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.
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MeSH Terms
Adrenal Medulla / embryology,  metabolism*
Enkephalin, Methionine / metabolism*
Epinephrine / metabolism*
Gestational Age
Norepinephrine / metabolism*
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; 58569-55-4/Enkephalin, Methionine

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